Analysis of influencing factors on the efficacy of platelet transfusion in patients with acute leukemia
Objective To analyze the influencing factors of platelet transfusion efficacy in patients with acute leukemia.Methods A total of 143 patients with acute leukemia treated in our department from April 2019 to April 2023 were selected as the study subjects.Platelet transfusion was administered based on the criteria of platelet count≤10×109/L or>10×109/L with evident signs of bleeding.All patients were infused with single collected platelets,and the efficacy was evaluated based on the platelet growth index combined with the improvement of bleeding.Compare the patient's gender,age,blood type,WBC count,AL type,number of transfusions,platelet inventory period,presence of fever,infection,splenomegaly,and medication use.Logistic regression analysis was used to analyze the influencing factors of efficacy.Results Univariate analysis showed no statistically significant differences in gender,age,AL type,blood type,platelet inventory period,whether bone marrow transplantation was performed,and whether DIC was present(P>0.05).However,significant differences were observed in WBC count,infusion frequency,splenomegaly,fever,infection,and antibiotic use(P<0.05).Logistic regression analysis shows WBC>50×109/L.Infusion frequency>5 times,splenomegaly,and infection are independent risk factors for ineffective platelet transfusion(OR=1.531,1.736,1.136,2.010,P<0.05).Conclusion Patients with abnormal elevation of WBC count,splenomegaly,infection,and multiple transfusions are at higher risk of ineffective platelet transfusion.Early interventions should be implemented to improve patient prognosis.
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