胃肠道恶性肿瘤患者化疗期间主要症状与生活质量的相关性研究
Study on correlation between main symptoms and quality of life in patients with gastrointestinal malignancies during chemotherapy
王晨 1丁英 1刘素娟 1杨晓文1
作者信息
摘要
目的 探索胃肠道恶性肿瘤患者化疗期间主要症状对生活质量的影响,为胃肠道恶性肿瘤症状高效管理提供依据.方法 选取2021年1月～2023年1月间无锡市锡山人民医院收治的胃肠道恶性肿瘤化疗期患者 170 例,采用安德森症状评估量表(M.D.Anderson symptom inventory,MDASI)对患者的症状进行问卷调查评估,综合各项因素进行多元逐步回归分析.结果 170例胃肠道恶性肿瘤化疗期间症状群患者MDASI平均得分为(74.72±24.83)分,严重程度较高的3个主要症状为悲伤(4.82±1.47)分、睡眠不安(4.59±1.25)分、疲乏(4.54±1.48)分.胃肠道恶性肿瘤患者化疗期间生活质量总得分为(69.70±11.02)分,患者化疗期间主要症状评分与生活质量评分呈负相关.患者的年龄、肿瘤分期、病程、化疗次数、不良反应与血小板计数为影响胃肠道恶性肿瘤患者化疗期生活质量困扰的主要影响因素.多元回归结果 显示,悲伤症状评分与睡眠不安症状评分均为生活质量较强的影响因素(P<0.001,R=0.406).结论 胃肠道恶性肿瘤患者化疗期生活质量的困扰主要与肿瘤分期、悲伤症状评分和睡眠不安症状评分等因素有关,临床上对胃肠道恶性肿瘤患者的医疗康复方案的制定与优化可以此为基点方面出发,旨在减少化疗期主要症状的影响,提高管理效果,使患者生活质量得到提升.
Abstract
Objective To explore the impact of main symptoms on quality of life in patients undergoing chemotherapy for gastrointestinal malignancies,aiming to provide evidence for effective symptoms management in this population.Methods A cohort of 170 patients with gastrointestinal malignancies undergoing chemotherapy were assessed for symptoms using the M.D.Anderson Symptom Inventory(MDASI).Multiple stepwise regression analysis was conducted to identify the factors influencing symptom severity.Results The average MDASI score among patients with gastrointestinal malignancy undergoing chemotherapy was(74.72±24.83).The top three symptoms with the highest severity were sadness(4.82±1.47),sleep disturbance(4.59±1.25)and fatigue(4.54±1.48).The total quality of life score of patients with gastrointestinal malignancies during chemotherapy was(69.70±11.02),and the score of main symptoms during chemotherapy was negatively correlated with the score of quality of life.The result of factor analysis showed that patients'age,tumor stage,course of disease,frequency of chemotherapy,toxic and side effects and platelet count were the main factors affecting the quality of life of patients with gastrointestinal malignancy during chemotherapy.Multiple regression result showed that sadness symptom score and sleep disturbance symptom score were both strong influencing factors of quality of life(P<0.001,R=0.406).Conclusion The disruption of quality of life in patients with gastrointestinal malignancies undergoing chemotherapy is primarily associated with factors such as tumor stage,sadness and sleep disturbance symptom score.Clinically,medical rehabilitation programs for these patients can be formulated and optimized to reduce the impact of main chemotherapy symptoms,thereby improving management effectiveness and improving overall quality of life.
关键词
胃肠道恶性肿瘤/胃癌/大肠癌/生活质量Key words
Gastrointestinal Malignancy/Gastric cancer/Colorectal cancer/Quality of life引用本文复制引用
基金项目
无锡老龄科研课题(22WXLNY031)
无锡市卫生健康委科技成果和适宜技术推广项目(T202220)
出版年
2024
NETL
NSTL
万方数据