The clinical value of HGI,β2-MG and HMGB1 in the early diagnosis of type 2 diabetic retinopathy
Objective To investigate the clinical value of glycosylated hemoglobin variation index(HGI),serum β2-microglobulin(β2-MG)and high mobility group protein B1(HMGB1)in the early diagnosis of type 2 diabetic retinopathy(DR).Methods A total of 112 patients with type 2 diabetes mellitus(T2DM)complicated with DR who were treated in Funan County Hospital of Traditional Chinese Medicine affiliated to West Anhui Health Vocational College from January 2020 to January 2023 were retrospectively selected as the study group,and 54 patients with simple T2 DM who were treated in the hospital during the same period were selected as the control group.The general data and the levels of HGI,β2-MG and HMGB1 were compared between the two groups.Multivariate logistic regression model was used to analyze the risk factors affecting DR in patients with T2 DM,and the receiver operating characteristic(ROC)curve was drawn.The diagnostic efficacy of HGI,β2-MG and HMGB1 alone and combined detection in T2DM patients with DR was analyzed.Results The proportion of hypertension in the study group was significantly higher than that in the control group(χ2=5.372,P<0.05).The duration of T2 DM,FPG,HbA1 c,LDL-C,HGI,β2-MG and HMGB1 levels in the study group were higher than those in the control group,and the differences were statistically significant(t=5.303,2.711,3.135,2.391,14.958,11.028,5.695,P<0.05).Multivariate logistic regression analysis showed that hypertension,HbA1 c,HGI,β2-MG and HMGB1 were risk factors for DR in patients with T2 DM(P<0.05).The result of ROC curve showed that the area under the curve(AUC)of DR in T2 DM patients with HGI,β2-MG and HMGB1 alone was 0.822,0.785 and 0.753,respectively,while the AUC of combined detection was 0.909,which was higher than that of single detection(P<0.05).Conclusion Levels of HGI,β2-MG and HMGB1 in T2 DM are elevated in T2DM patients with DR compared to those with simple T2DM,and these indicators are risk factors for DR.Combined detection of the three levels has good diagnostic efficacy for DR.
Hemoglobin glycation variability indexβ2-microglobulinHigh mobility group box-1 proteinDiabetic retinopathyEarly diagnosis
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