Correlation between monocyte to HDL cholesterol ratio and severity of coronary artery stenosis
Objective To investigate the correlation between monocyte-to-high-density lipoprotein cholesterol ratio(MHR)and SYNTAX score,further exploring the relationship between MHR and severity of coronary artery disease.Methods Retrospective analysis was conducted on the basic information and blood biochemical tests of 352 patients who underwent coronary angiography during their hospitalization in the Cardiology Department Zhongshan Hospital Qingpu Branch,affiliated with Fudan University,from June 2022 to June 2023.MHR was calculated,and based on the angiographic results,patients were divided into two groups:coronary heart disease group(≥50％)and non-coronary heart disease group(＜50％).Within the coronary heart disease group,further classification was done according to SYNTAX scoring system(WWW.syntaxscore.com),resulting in low score group(≤22 points),intermediate score group(23～32 points),and high score group(≥ 33 points).Results There was statistically significant difference in MHR between the non-coronary artery disease group and the coronary artery disease group(P＜0.05).Within the coronary artery disease group,MHR increased progressively from the low score subgroup to the medium score subgroup and then to the high score subgroup,with statistically significant differences observed between each pair of subgroups(P＜0.05).MHR was identified as an independent risk factor for coronary artery disease(OR=3.069,95％CI=1.082～8.705,P=0.035).SYNTAX scores were significantly positively correlated with MHR,as MHR values increased,both SYNTAX scores and severity of coronary lesions gradually increased.Conclusion MHR is positively correlated with SYNTAX score and significantly correlated with the severity of coronary artery disease,which is an independent risk factor for coronary heart disease.
Ratio of monocyte to high density lipoprotein cholesterolCoronary atherosclerotic heart diseaseSYNTAX score
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