Relationship between peripheral blood Hcy,NLR and lower extremity arterial disease in elderly patients with T2DM
Objective To discuss the relationship between peripheral blood homocysteine(Hey),neutrophil to lymphocyte ratio(NLR)and lower extremity arterial disease(LEAD)in elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 63 elderly patients with T2DM and LEAD who were admitted to Dangtu People's Hospital from January 2022 to October 2023 were selected and defined as LEAD group.Meanwhile,63 elderly patients with T2DM but without LEAD were selected for gender and age 1∶1 matching and defined as the T2DM group.Clinical data,peripheral blood Hey and NLR of the two groups were compared.The risk factors for LEAD in elderly patients with T2DM were identified.Results Peripheral blood Hey[(16.12±4.05)μmol/L vs.(13.48±3.16)μmol/L]and NLR[(3.02±0.76)vs.(2.25±0.50)]in LEAD group were higher than those in T2DM group(t=4.079,6.718,P＜0.05).TG(OR=3.053,P=0.007),LDL-C(OR=2.815,P=0.009),HbA1c(OR=3.040,P=0.002),fasting blood glucose(OR=2.552,P=0.028),2-hour postprandial blood glucose(OR=2.375,P=0.011),Hcy(OR=1.264,P=0.016)and NLR(OR=1.941,P=0.006)were risk factors for LEAD in elderly patients with T2DM(P＜0.05).Conclusion There is a close correlation between peripheral blood Hey,NLR and the occurrence of LEAD in elderly patients with T2DM,which can provide reference for the diagnosis and treatment of LEAD in elderly patients with T2DM.
Type 2 diabetes mellitusLower extremity arterial diseaseHomocysteineNeutrophil to lymphocyte ratio
万方数据
维普
