The correlation between Electroencephalogram(EEG)changes and 11C-PIB uptake in patients with Alzheimer's disease
Objective To explore the correlation between resting state electroencephalogram(rsEEG)changes and Pittsburgh Compound-B(11 C-PIB,a tracer of amyloid(Aβ)in PET/CT)uptake,in patients with Alzheimer's disease(AD).Methods Both rsEEG and 11C-PIB PET/CT examinations were completed in 13 AD patients recruited from Neurology clinic in Chinese PLA General Hospital from 2016 to 2019.The correlation between rsEEG metrics and 11C-PIB uptake was analyzed.Results The negative correlations between average alpha peak frequency(AAPF)and standardized uptake value ratio(SUVR)of 11C-PIB were found in the left frontal lobe and the right frontal lobe in patients with AD(r=-0.81,0.79,P＜0.01).Another negative correlation between spectral entropy of δ rhythm and 11C-PIB SUVR was found in the left temporal lobe(r=-0.83,P＜0.01).Conclusions The burden of Aβ in cerebral cortex is correlated to rsEEG changes in the corresponding cortex in AD patients.More severe Aβ burden in bilateral frontal lobe and left temporal lobe,lower rsEEG activity is observed.Our results provide more clues for the mechanism of EEG changes in patients with AD.
Alzheimer's diseaseResting state electroencephalogramAmyloid11C-PIBPET/CT
万方数据
维普
