Feasibility of electronystagmogram follow-up test for screening patients with Parkinson's disease
Objective To explore the feasibility of electronystagmogram follow-up test in screening patients with Parkinson's disease.Methods Retrospectively selected 188 subjects who underwent the nystagmographic visual tracking experiment in our hospital from February 2020 to February 2023,and were divided into the onset group(60 cases)and the healthy group(128 cases)according to whether Parkinson's occurred or not.All of them had their oculomotor system examined using a video nystagmograph,observed the general data of the 2 groups,and analysed the independent predictors affecting the onset of Parkinson's disease patients and constructed a prediction model;further analysed the differences of the independent predictors of Parkinson's disease patients with different Hoehn-Yahr grades,and analysed the predictive value for different degrees of onset.Results Among 188 investigators,there were 60 patients with PD and 128 healthy subjects.The saccade speed of patients in the attack group with left saccade angles of 20 and 25 and right saccade angles of 15 and 30 was longer than that of the healthy group(P＜0.05).Logistic regression showed that left saccade angles of 20 and 25 and right saccade angles of 15 and 30 were independent predictors of PD patients.Comparing patients with different Hoehn-Yahr grades,it was found that the scanning speed of left angles 20 and 25 and right angles 15 and 30 became slower with the development and worsening of the disease.Logistic regression showed that left saccade angles 20 and 25 and right saccade angles 15 and 30 were independent predictors of PD progression.The ROC results showed that the AUC of the combination of left eye angle 20,25 and right eye angle 15,30 was 0.988,and the sensitivity and specificity were 99.00％and 98.00％,respectively,which had the highest predictive value.Conclusion Left gaze angle 20,25 and right gaze angle 15,30 are predictors of Parkinson's disease,and the difference is more significant as the disease worsens.The combined diagnosis of left gaze angle 25 and right gaze angle 15,30 has a higher predictive value for the onset and progression of Parkinson's disease,so dynamic monitoring of changes in related predictors may provide a scientific basis and theoretical guidance for clinical prevention and early diagnosis of Parkinson's disease.
Electronystagmogram visual tracking experimentParkinson's diseaseOnset of diseaseScreening
万方数据
维普
