Correlation analysis of serum SCCA,ProGRP and NSE,pathological characteristics and objective response to chemotherapy in elderly patients with non-small cell lung cancer
Objective To analyze the correlation among serum squamous cell carcinoma antigen(SCCA),progastrin-releasing peptide(ProGRP)and neuron specific enolase(NSE),pathological characteristics and objective response to chemotherapy in elderly patients with non-small cell lung cancer(NSCLC).Methods 80 elderly patients with NSCLC who underwent standard chemotherapy in the hospital were selected and divided into partial remission(PR)group,stable disease(SD)group and progression of disease(PD)group according to the objective response to chemotherapy.Serum SCCA,ProGRP and NSE levels were compared among patients with different pathological characteristics and different objective responses to chemotherapy.Correlation analysis was conducted.Results Serum SCCA,ProGRP and NSE levels in patients at stage Ⅳ and with lymph node metastasis were higher than those in patients at stage Ⅲ and without lymph node metastasis(P＜0.05).Serum SCCA,ProGRP and NSE were positively correlated with TNM staging and lymph node metastasis(P＜0.05).The levels of SCCA,ProGRP and NSE in PR group after chemotherapy were lower than those in SD group and PD group(P＜0.05).The levels of SCCA and NSE in SD group after chemotherapy were lower than those in PD group(P＜0.05).After chemotherapy,SCCA,ProGRP and NSE were negatively correlated with the objective response to chemotherapy(P＜0.05).Conclusion Serum SCCA,ProGRP and NSE are closely related to TNM staging,lymph node metastasis and objective response to chemotherapy in elderly patients with NSCLC.
Non-small cell lung cancerSquamous cell carcinoma antigenProgastrin-releasing peptideNeuron specific enolasePathologyChemotherapy
万方数据
维普
