Effects of milrinone combined with non-invasive ventilator on blood gas,myocardial damage and short-term adverse events in elderly patients with pulmonary heart disease and acute heart failure
Objective To investigate the effects of milrinone combined with non-invasive ventilator on blood gas,myocardial damage and short-term adverse events in elderly patients with pulmonary heart disease(PHD)and acute heart failure(AHF).Methods Sixty elderly patients with PHD and AHF who were admitted to the Emergency Department of Dangtu People's Hospital from July 2021 to July 2023 were selected and divided into a ventilator group and a combination group using the random number table,with 30 patients in each group,patients in the ventilator group were treated with non-invasive ventilator based on conventional treatment,and patients in the combination group were treated with milrinone on the basis of the treatment of ventilator group.Both groups of patients were treated for 7 d.Blood gas indicators,myocardial damage indicators,cardiac function indicators,pulmonary artery pressure indicators,and short-term adverse events were compared between the two groups.Results After treatment,partial pressure of oxygen(PaO2),oxygenation index(P/F),and oxygen saturation(SaO2)in the combination group were higher than those in the ventilator group.Partial pressure of carbon dioxide(PaCO2)was lower than that in the ventilator group(t=3.840,12.871,4.200,8.735,P＜0.05).After treatment,the levels of myoglobin(Mb),cardiac troponin Ⅰ(cTn Ⅰ),and creatine kinase isoenzyme(CK-MB)in the combination group were lower than those in the ventilator group(t=6.330,6.043 and 13.997,P＜0.05).After treatment,the right ventricular Tei index in the combination group was lower than those in the ventilator group,right ventricular ejection fraction(RVEF)and tricuspid annular plane systolic excursion(TAPSE)were higher than those in the ventilator group(t=2.274,2.931,3.532,P＜0.05).After treatment,pulmonary systolic blood pressure(PASP),mean pulmonary artery pressure(MPAP)in the combination group were less than that in the ventilator group(t=2.970 and 5.273,P＜0.05).There was no statistically significant difference in the rate of adverse reactions and the incidence of short-term adverse events between the two groups(Fisher=0.424).Conclusion The combined treatment with milrinone and non-invasive ventilator can effectively improve blood gas indicators and myocardial damage in elderly patients with PHD and AHF,and reduce their pulmonary artery pressure.
万方数据
维普
