Correlation between the expression of miR-192 and miR-196a and the efficacy of chemotherapy in patients with HER-2-negative advanced gastric cancer
Objective To observe the relationship between the expression levels of miR-192 and miR-196a in tumor tissue and serum of HER-2 negative gastric cancer patients and the short-term efficacy of fluorouracil combined with oxaliplatin chemotherapy regimen.Methods 93 patients with advanced gastric cancer treated with Xelox regimen or SOX regimen were collected and divided into chemotherapy sensitive group and chemotherapy resistant group based on their recent efficacy.Compare the expression levels of miR-192 and miR-196a in tumor tissue and plasma of two groups of patients,and analyze the correlation between the expression levels and recent therapeutic effects using Spearman method.Results Compared with adjacent tissues,both miR-192 and miR-196a were overexpressed in gastric cancer tissue(t=19.081,31.297,P＜0.05).The expression of miR-192 in tissues and plasma of the chemotherapy-sensitive group were both lower than those of the resistant group,the expression of miR-196a in the tissue and plasma of the sensitive group were both lower than those of the resistant group(t=7.355,10.713,4.110,3.027,P＜0.05).The expression of miR-192 was positively correlated with chemotherapy sensitivity,with correlation coefficients of 0.577 and 0.482 for tissue and plasma expression,respectively.The expression level of miR-196a was negatively correlated with chemotherapy sensitivity,with correlation coefficients of-0.474 and-0.413 for tissue and plasma expression,respectively.There is a positive correlation between miR-192 and miR-196a in the gastric cancer tissue and plasma of patients,with correlation coefficients of 0.784 and 0.698,respectively.Conclusion The expression level of miR-192 in tumor tissue and serum of HER-2 negative gastric cancer patients is positively correlated with the short-term efficacy of SOX and Xelox chemotherapy regimens,while the expression level of miR-196a is negatively correlated with the short-term efficacy of SOX and Xelox chemotherapy regimens.Detecting the expression of plasma miR-192 and miR-196a may achieve dynamic monitoring of drug resistance.
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