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食管癌术后早期经口进食安全性及近期生命质量的单中心研究

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目的 观察基于加速康复外科(ERAS)理念的食管癌术后早期经口进食安全性及对患者生命质量的影响。方法 选取2020年8月~2023年6月于空军军医大学第二附属医院胸外科就诊的127例食管癌患者,随机数表法分为早期进食组(n=64)和晚期进食组(n=63)。比较两组患者术后首次排气、首次排便时间、住院时间及并发症发生率。于术前、术后1周及术后4周采用生命质量测定量表(QLQ-C30)评估患者的生命质量。结果 早期进食组患者术后首次排气时间、术后首次排便时间及住院时间均短于晚期进食组患者[(2。1±0。7)d vs。(3。4±0。9)d、(3。5±1。1)d vs。(5。7±1。5)d、(7。8±3。1)dvs。(11。4±5。8)d],差异均有统计学意义(t=9。094、9。435、4。371,P<0。05)。早期进食组患者的并发症总发生率为39。06%(25/64),与晚期进食组患者的并发症总发生率为36。51%(23/63)比较,差异无统计学意义(P>0。05)。术后1和4周,早期进食组患者综合生命质量和功能维度评分均高于晚期进食组患者,症状维度评分低于晚期进食组患者,差异均有统计学意义(t=2。623、4。014、3。327、2。353,P<0。05)。术后1和4周,两组患者单一条目症状和经济困难的评分比较,差异均无统计学意义(t=2。077、3。051,P>0。05)。结论 对于行微创食管癌根治术的患者,采用基于ERAS理念的术后早期经口进食方案可促进患者胃肠功能恢复,缩短患者住院时间,改善患者生命质量,且未明显增加术后并发症发生的风险。
A single center study on the safety and short-term quality of life of early oral feeding after esophageal cancer surgery
Objective To observe the safety of early postoperative oral feeding based on the concept of rapid rehabilitation surgery and its impact on the short-term quality of life of patients.Methods A prospective study was conducted on patients who underwent minimally invasive radical surgery for esophageal cancer in our center.130 patients were randomly divided into two groups:the early feeding group and the late feeding group,with 65 cases in each group.Compare postoperative exhaust,defecation time,hospital stay,and incidence of complications between two groups.Evaluate the recent quality of life of patients using the European Organization for the Treatment of Cancer(EORTC)Quality of Life Inventory QLQ-C30 before surgery,1 week after surgery,and 4 weeks after surgery.Results A total of 127 patients completed the study,with 64 in the early eating group and 63 in the late eating group.The time of first postoperative defecation and hospitalization in the early eating group were(2.1±0.7)d,(3.5±1.1)d,(7.8±3.1)d,shorter than that in the late eating group(3.4±0.9)d,(5.7±1.5)d,(11.4±5.8)d(t=9.094,9.435,4.371,P<0.05).The incidence of complications in two groups was 38.06%vs.36.51%(x2=0.088,P=0.767).There was no statistically significant difference in the scores of each dimension of the QLQ-C30 scale between the two groups one week before surgery(P>0.05).At 1 week and 4 weeks after surgery,the comprehensive quality of life dimension and functional dimension of the early eating group were higher than those of the late eating group's(t=2.623,4.014,3.327,2.353,P<0.05).The symptom dimension score were lower than that of the late eating group's(t=2.077,3.051,P<0.05).There was no statistically significant difference in the score of a single item and the score of economic difficulties between 1 week and 4 weeks after surgery,with(P>0.05).Conclusion Early postoperative oral feeding based on the concept of rapid recovery surgery can promote gastrointestinal function recovery,shorten hospital stay,improve short-term quality of life for patients undergoing minimally invasive esophageal cancer radical surgery,and does not significantly increase the risk of postoperative complications.

Accelerated rehabilitation surgeryNurseEsophageal cancerEarly oral feedingQuality of life

房雅君、李文萍、雷杰

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710038 西安,空军军医大学第二附属医院胸腔外科

加速康复外科 护理 食管癌 早期经口进食 生命质量

陕西省科技厅重点研发计划

2023-YBSF-318

2024

中华保健医学杂志
中国人民解放军总后勤部卫生部保健局

中华保健医学杂志

CSTPCD
影响因子:0.477
ISSN:1674-3245
年,卷(期):2024.26(4)