首页|身痛逐瘀汤降低急性骨骼肌损伤疼痛的疗效及对血清炎性因子的影响分析

身痛逐瘀汤降低急性骨骼肌损伤疼痛的疗效及对血清炎性因子的影响分析

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目的 探讨身痛逐瘀汤对急性骨骼肌损伤的疗效及作用机理。方法 选取2023年1月~2023年7月在解放军总医院就诊的82名急性骨骼肌损伤患者,随机数表法分为中药组和西药组,各41例。中药组给予身痛逐瘀汤治疗,西药组给与双氯芬酸钠双释放肠溶胶囊治疗。观察两组患者受损骨骼肌疼痛评分及血清炎症因子变化。结果 治疗7 d后,中药组患者的疼痛评分低于西药组[(0。61±0。80)分vs。(1。46±1。43)分],差异有统计学意义(t=-3。327,P<0。05);中药组患者的TNF-α、IL-6、CRP、IL-8 低于西药组[(4。82±2。24)pg/ml vs。(9。10±3。47)pg/ml、(2。09±1。52)pg/ml vs。(3。24±2。11)pg/ml、(0。34±0。20)mg/dlvs。(0。49±0。26)mg/dl、(26。13±13。23)pg/ml vs。(36。72±16。68)pg/ml],差异均有统计学意义(t=-6。650、-2。846、-3。125、-3。184,P<0。05)。结论 身痛逐瘀汤治疗急性骨骼肌损伤可以明显减轻疼痛程度,抑制炎性因子的释放是其部分作用机制,值得在临床应用。
The therapeutic effect of Shentong Zhuyu Decoction on reducing acute skeletal muscle injury pain and its impact on serum inflammatory factors
Objective To explore body pain by stasis soup curative effect and mechanism of acute skeletal muscle injury.Methods Eighty-two individuals suffering from acute skeletal muscle injuries were randomly assigned to either a traditional Chinese medicine cohort or a Western medicine cohort.The TCM group received Shentongzhuyu Decoction,and the Western medicine group received diclofenac sodium dual-release enteric-coated capsules.Observe two groups of patients with impaired skeletal muscle pain score and serum inflammatory factors change.Results Following a week of treatment with traditional Chinese medicine,individuals in this cohort experienced a reduced pain index of(0.61±0.80),notably less than the(1.46±1.43)recorded in the group receiving Western medical treatments,indicating a considerable statistical variance between the two factions(t=-3.337,P<0.05).Moreover,in the cohort treated with traditional Chinese medicine,the levels of TNF-α,IL-6,CRP,and IL-8 were observed at 4.82±2.24 pg/ml,2.09±1.52pg/ml,0.34±0.20mg/dL and 26.13±13.23pg/ml,respectively.Compared with the western medicine group 9.10±3.47pg/ml,3.24±2.11 pg/ml,0.49±0.26mg/dL,36.72±16.68pg/ml,there were significant statistical differences(t=-6.650,-2.846,-3.125,-3.184,P<0.05).Conclusion The treatment of acute skeletal muscle injury with Shen Tong Zhu Yu Decoction can significantly reduce the degree of pain,and its partial mechanism of action is to inhibit the release of inflammatory factors,which is worth promoting and applying in clinical practice.

Shentongzhuyu DecoctionAcute injury of skeletal musclePainscoreInflammatory factor

冯宇、谢东晴

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1000853北京,解放军总医院第六医学中心中医医学部

解放军总医院第一医学中心超声科

身痛逐瘀汤 急性骨骼肌损伤 疼痛评分 炎性因子

军队中医药服务能力培育与提升专项计划项目

2021ZY050

2024

中华保健医学杂志
中国人民解放军总后勤部卫生部保健局

中华保健医学杂志

CSTPCD
影响因子:0.477
ISSN:1674-3245
年,卷(期):2024.26(4)