Assessment of the GRACE and TIMI scores for predicting adverse cardiovascular events in patients with non-ST-segment elevation acute coronary syndrome
Objective To evaluate the predictive value of the Global Registry of Acute Coronary Events(GRACE)and Thrombolysis in Myocardial Infarction(TIMI)scores for adverse cardiovascular events in patients with non-ST-segment elevation acute coronary syndrome(NSTE-ACS).Methods Clinical data of NSTE-ACS patients admitted from January 2020 to November 2023 were collected.Patients were categorized into low-risk,medium-risk,and high-risk groups based on GRACE and TIMI scores.The incidence of adverse cardiovascular events within 30 days of symptom onset was recorded.The incidence rates of adverse cardiovascular events across different risk strata were compared,and the area under the receiver operating characteristic(ROC)curve(AUC)was calculated to assess the predictive value of the GRACE and TIMI scores.Results The proportion of low-risk patients was not significantly different between the TIMI(23.35%,60∕257)and GRACE(18.68%,48∕257)scoring systems(P>0.05).The proportion of medium-risk patients was higher in the TIMI scoring system(62.65%,161∕257)compared to the GRACE system(40.47%,104∕257),while the proportion of high-risk patients was lower in the TIMI system(14.00%,36∕257)than in the GRACE system(40.86%,105∕257),with statistically significant differences(t=25.308,48.101,P<0.05).The overall incidence of adverse cardiovascular events differed significantly between the two scoring systems(χ2=24.403,P<0.05),but mortality rates did not(χ2=0.778,P>0.05).The AUC for the GRACE score in predicting adverse cardiovascular events was 0.756,which was higher than that of the TIMI score at 0.603.Conclusion Both the GRACE and TIMI risk scores are applicable for assessing the risk of adverse cardiovascular events in NSTE-ACS patients,with the GRACE score showing a higher predictive value.
Global registry of acute coronary events scoreThrombolysis in myocardial infarction scoreNon-ST-segment elevation acute coronary syndromeAdverse cardiovascular eventsPredictive value
万方数据
维普
