Correlation of peripheral blood MPO level with hypertension and carotid plaque formation
Objective To observe the changes of myeloperoxidase(MPO)level in peripheral blood of patients with hypertension,and to explore and analyze its association with the the occurrence and grading of hypertension and carotid plaque formation.Methods From December 2023 to March 2024,198 patients with hypertension were retrospectively included in the study,and another 198 healthy people were selected for the control group.By measuring the level of MPO in peripheral blood,its association with hypertension occurrence and carotid plaque formation was analyzed.Results The level of MPO in peripheral blood of patients with hypertension was(15.33±4.25)ng∕L,which was significantly higher than that of the control group with(10.47±2.28)ng∕L(t=14.190,P<0.05).The difference was statistically significant in peripheral blood MPO level among patients with hypertension grade 1,2 and 3[(13.10±3.06)ng∕L vs.(16.03±3.24)ng∕L vs.(20.30±4.29)ng∕L](F=59.954,P<0.05).The level of MPO in patients with grade 3 was significantly higher than that in patients with grade 1 and grade 2(q=15.214,8.540,P<0.05),and the level of MPO was significantly higher in patients with grade 2 than that in patients with grade 1(q=7.767,P<0.05).The level of peripheral blood MPO was(17.99±4.17)ng∕L in hypertensive patients with carotid plaque formation,which was significantly higher than(14.48±3.92)ng∕L in patients without carotid plaque formation(t=5.322,P<0.05).Spearman correlation showed that the peripheral blood MPO level was positively correlated with the occurrence and grading of hypertension and carotid plaque formation(r=0.612,0.587,0.351,P<0.05).Logistic regression analysis revealed that age,diabetes mellitus,hyperlipidemia,smoking,drinking and MPO level were the risk factors for hypertension(OR=1.675,2.192,2.815,1.939,1.423,1.206,2.440,P<0.05),and diabetes mellitus,hyperlipidemia and MPO level were the risk factors for the formation of carotid plaque(OR=1.902,2.065,2.818,P<0.05).The ROC curve showed that the AUC of peripheral blood MPO levels for assessing the risk of developing hypertension was 0.853,with a sensitivity of 0.768,a specificity of 0.818,and a 95%CI=0.815～0.891,The AUC for assessing the progression of hypertension to grades 2 and 3 was 0.804,with a sensitivity of 0.822 and a specificity of 0.670,95%CI=0.745～0.864,and for assessing the presence of carotid plaque formation in hypertension was 0.736,with a sensitivity of 0.875 and a specificity of 0.513,95%CI=0.660～0.813.Conclusion There is a certain association between the level of peripheral blood MPO and the occurrence,grading and carotid plaque formation of hypertension,and it has certain evaluated value on the occurrence,progression and carotid plaque formation of hypertension.
万方数据
维普
