Correlation analysis between geriatric nutritional risk index and sarcopenia in elderly patients after radical gastrectomy for gastric cancer
Objective To explore the correlation between the Geriatric Nutritional Risk Index(GNRI)and sarcopenia in elderly patients following radical gastrectomy for gastric cancer.Methods A retrospective analysis was conducted on 260 elderly patients who underwent radical gastrectomy for gastric cancer at Jiangning Hospital from February 2021 to February 2024.Patients were categorized into sarcopenia(n=145)and non-sarcopenia groups(n=115)based on the European Working Group on Sarcopenia in Older People(EWGSOP2)criteria.Clinical data of both groups were analyzed.A multivariate logistic regression model was utilized to identify risk factors for sarcopenia post-radical gastrectomy.The Receiver Operating Characteristic(ROC)curve analysis was employed to assess the diagnostic value of GNRI in combination with other indices for sarcopenia after radical gastrectomy in elderly patients.Pearson's correlation analysis was also used to investigate the relationship between GNRI and sarcopenia-related indicators.Results The prevalence of sarcopenia among the 260 elderly patients was 55.77%(145∕260).Multivariate logistic regression analysis indicated that age,Body Mass Index(BMI),albumin(ALB),neutrophil-to-lymphocyte ratio(NLR),and GNRI were independent risk factors for sarcopenia following radical gastrectomy(P<0.05).The ROC curve analysis revealed that a combination of age,BMI,ALB,NLR,and GNRI as predictors demonstrated high diagnostic efficacy for sarcopenia after radical gastrectomy in elderly patients,with an AUC of 0.874,sensitivity of 80.5%,and specificity of 76.5%.Pearson's correlation analysis showed that GNRI was positively correlated with sarcopenia-related indicators(handgrip strength,skeletal muscle index,and gait speed)with coefficients(r)of 0.268,0.364,and 0.273,respectively(P<0.05).Conclusion There is a significant correlation between GNRI and the occurrence of sarcopenia in elderly patients after radical gastrectomy for gastric cancer,which is of considerable clinical importance for the early detection and intervention of sarcopenia in this patient population.
万方数据
维普
