首页|NPR、HBP及APACHEⅡ评分对呼吸衰竭患者预后的评估价值

NPR、HBP及APACHEⅡ评分对呼吸衰竭患者预后的评估价值

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目的 分析外周血中性粒细胞与血小板计数比值(NPR)、肝素结合蛋白(HBP)及急性生理与慢性健康评估(APACHEⅡ)评分在呼吸衰竭患者预后中的评估价值及意义.方法 回顾性选取 2021 年 5 月~2023 年 5 月在马鞍山十七冶医院重症医学科住院的呼吸衰竭患者 140 例,收集其临床资料,并于入院 24 h内检测患者血小板计数(PLT)、HBP、D-二聚体、C反应蛋白(CRP)、血气[动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)]、APACHEⅡ评分等指标,根据观察终点(入院后28 d)存活情况将患者分为存活组(n=105 例)与死亡组(n=35 例),采用Pearson相关性分析法与logistic回归分析法观察各个指标之间及其与预后的相关性.结果 死亡组 PLT、PaO2 均低于存活组,NPR、HBP、D-二聚体、CRP、PaCO2、APACHEⅡ评分均高于存活组,差异具有统计学意义(t=3.750、4.588、12.868、11.014、3.353、9.804、7.303、6.710,P<0.05).经Pearson相关性分析得出,呼吸衰竭患者NPR、HBP、APACHEⅡ评分与PLT、PaO2 均呈负相关(P<0.05),与D-二聚体、CRP、PaCO2 均正相关(P<0.05);以入院后 28 d的存活情况为因变量,以 PLT、PaO2、NPR、HBP、D-二聚体、CRP、PaCO2、APACHEⅡ评分为自变量进行logistic回归分析得出,NPR、HBP、PaCO2、APACHEⅡ评分为呼吸衰竭患者预后不良的危险因素(P<0.05).结论 呼吸衰竭患者预后不良发生率较为严重,NPR、HBP、PaCO2、APACHEⅡ评分等指标水平较高,对患者预后评估具有较好价值,且临床需要对上述指标升高的患者引起重视,借助指标监测及诊治来改善患者预后.
Value of NPR,HBP,and APACHEⅡ score in assessing the prognosis of patients with respiratory failure
Objective his study aimed to evaluate the prognostic value and significance of the NPR,HBP,and APACHEⅡscore in patients with respiratory failure.Methods We retrospectively analyzed 140 cases of respiratory failure admitted to the Department of Critical Care Medicine at Maanshan Shiqiye Hospital from May 2021 to May 2023.Clinical data were collected,and measurements including PLT,HBP,D-dimer,CRP,blood gas levels(PaO2 and PaCO2),and APACHEⅡ score were conducted within 24 hours of admission.Patients were categorized into survival(n=105)and death(n=35)groups based on their 28-day survival post-admission.Pearson correlation and logistic regression analyses were applied to assess the correlation between these indicators and patient prognosis.Results The death group exhibited lower PLT and PaO2 compared to the survival group.Conversely,NPR,HBP,D-dimer,CRP,PaCO2,and APACHE Ⅱ score were higher in the death group than in the survival group.Statistically significant differences were observed(t=3.750,4.588,12.868,11.014,3.353,9.804,7.303,6.710,P<0.05).Pearson correlation analysis revealed that NPR,HBP,and APACHE Ⅱ score were negatively correlated with PLT and PaO2 and positively correlated with D-dimer,CRP,and PaCO2 in patients with respiratory failure(P<0.05).Logistic regression analysis identified NPR,HBP,PaCO2,and APACHE Ⅱ score as risk factors for poor prognosis in respiratory failure patients(P<0.05).Conclusion The incidence of poor prognosis is significant in patients with respiratory failure,with elevated levels of NPR,HBP,PaCO2,and APACHE Ⅱ score being valuable for prognosis assessment.Clinical attention should be given to patients with increased values of these indicators to improve their prognosis through monitoring and treatment.

Peripheral blood neutrophil-to-platelet ratioHeparin-binding proteinAcute physiology and chronic health evaluationRespiratory failure

朱瑶、董雪梅、晋小祥

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243000 马鞍山十七冶医院重症医学科

中性粒细胞与血小板计数比值 肝素结合蛋白 急性生理与慢性健康评估 呼吸衰竭

安徽省卫生健康委科研项目

AHWJ2023a059

2024

中华保健医学杂志
中国人民解放军总后勤部卫生部保健局

中华保健医学杂志

CSTPCD
影响因子:0.477
ISSN:1674-3245
年,卷(期):2024.26(5)