Clinical efficacy and safety exploration of lanthanum carbonate combined with paricalcitol on the treatment of MHD patients with chronic kidney disease
Objective To analyze the effect of lanthanum carbonate combined with paricalcitol on patients treated with maintenance hemodialysis(MHD)for chronic kidney disease.Methods 94 patients with chronic kidney disease MHD diagnosed and treated in the First People's Hospital of Cebu City from January 2022～December 2023 were selected and divided into the observation group and the control group by random lottery method,47 cases each.The control group was given paricalcitol treatment,and the observation group was given paricalcitol+lanthanum carbonate treatment,and the two groups were compared in terms of clinical outcome,anthropometric indexes,calcium and phosphorus metabolism indexes,nutritional status,level of inflammatory factors,coronary artery calcification indexes,left ventricular hypertrophy,adverse reactions,and quality of life.Results There was a difference in the total response rate between the two groups(97.87%vs.82.98%)(χ2=4.424,P<0.05).After treatment,the levels of TSF and MAC in the observation group were higher(t=8.822,5.534,P<0.05).The level of calcium and phosphorus metabolism indexes in the observation group was lower(t=5.147,9.027,74.112,4.375,P<0.05),and Comparison of serum calcium between the two groups was insignificant(t=0.449,P>0.05).After treatment,the observation group had lower levels of inflammatory factors(t=3.745,4.531,12.813,P<0.05).After treatment,the observation group had lower levels of CACS and LVMI(t=14.350,13.240,P<0.05).After treatment,the KDQOL-SF score in the observation group was higher(t=4.586,P<0.05).The incidence of adverse reactions between the two groups was insignificant(6.38%vs.2.13%)(χ2=0.261,P>0.05).Conclusion Lanthanum carbonate combined with paricalcitol can improve calcium and phosphorus metabolism and nutritional status in patients treated with chronic kidney disease MHD,alleviate inflammation,improve coronary artery calcification indexes and left ventricular hypertrophy,and improve the quality of life of patients.
Lanthanum carbonateParicalcitolChronic kidney diseaseMaintenance hemodialysisCalcium and phosphorus metabolismNutritional status
万方数据
维普
