阿比朵尔胶囊在中国汉族和藏族健康人体的药动学研究
Study on Pharmacokinetics of Arbidol Capsules in Chinese Han and Tibetan Healthy Volunteers
李忠亮 1王晓波 1袭荣刚 1张治然1
作者信息
- 1. 116021 辽宁大连,解放军210医院药剂科
- 折叠
摘要
目的 研究汉族和藏族健康志愿者单剂量口服阿比朵尔胶囊的药动学.方法 健康志愿者20名(其中汉族、藏族各10名,男女各半),单剂量口服阿比朵尔胶囊200 mg,采用HPLC法测定血浆中阿比朵尔的含量.采用DAS2.1软件程序进行数据处理,并用SPSS统计学软件进行分析.结果 受试者单剂量口服阿比朵尔胶囊200 mg后,汉族健康志愿者主要药动学参数为:Cmax为( 783.83±164.29) ng/ml,tmax为(1.31±0.62)h,t1/2为(10.39±2.84)h,AUC0-48为(6372.2±1139.4) ng·h/ml；AUC0-∞为(6831.3±1341.2) ng·h/ml.藏族健康志愿者主要药动学参数为:Cmax为(752.2±137.5) ng/ml,tmax为(1.66±0.64)h,t1/2为(10.71±4.35)h,AUC0-48为(6488.5 +1293.7) ng·h/ml; AUC0-∞为(7018.4±1621.8)ng·h/ml.结论 健康志愿者单剂量口服阿比朵尔胶囊的体内药动学过程符合一室模型.经统计学分析,汉族和藏族健康志愿者药动学过程不存在种族、性别差异.
Abstract
Objective To study the pharmacokinetics of arbidol capsules after a single oral dose in Han and Tibetan healthy volunteers. Methods Ten Han healthy volunteers and ten Tibetan healthy volunteers were involved in the study. Each subject received a single dose of 200 rag arbidol capsules. The plasma concentration was determined by HPLC. The pharmacokinetic parameters were calculated by DAS software and were statistically analyzed by SPSS software. Results The main pharmacokinetic parameters of Han nationality subjects were as follows: C ^ was (783.83 ±164.29 ) ng/ml,t was (1.31 ±0.62) h,t1/2was (10.39 ±2.84) h, AUC0-48, was (6372.2 ± 1139.4) ng oh/ml:AUC0.. Was (6831. 3 + 1341. 2) ng -h/ml. Those of Tibetan subjects were as follows: C m was (752.2 ±137.53) ng/ml, tmax,was( 1.66 ±0.64) h, t1/2 was( 10.71 ±4.35) h.AUC0-48 was(6488.5 ±1293.7) ng oh/ml:AUC0-∞ was (7018.4 ± 1621. 8)ng ·h/ml. Conclusion The plasma concentration-time curve of arbidol fits with an one-compartment model and the main pharmacokinetic parameters of arbidol are not significantly different between Han and Tibetan volunteers of both genders.
关键词
阿比朵尔/药动学/汉族/藏族Key words
arbidol/pharmacokinetics/Han nationality/Tibetan natiorality引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据