西洋参醇提取液对模拟高原暴露小鼠的抗疲劳作用研究
Anti-fatigue Function of Panax Quinquefoiuml in Mice Under Simulated Plateau Conditions
周思敏 1田怀军 1黄庆愿 2高钰琪 2张钢1
作者信息
- 1. 400038重庆,第三军医大学 高原军事医学系高原军队卫生学教研室,高原医学教育部重点实验室,全军高原生理与高原病研究重点实验室
- 2. 400038重庆,第三军医大学 高原军事医学系病理生理学与高原生理学教研室
- 折叠
摘要
目的 探讨西洋参醇提取液对模拟高原环境暴露小鼠的抗疲劳作用.方法 100只雄性昆明小鼠随机分成5组(n=20),分别是溶剂对照组、红景天阳性对照组(0.87 g·kg-1)、西洋参低、中、高(0.29、0.86、8.6 g·kg-1)剂量组.小鼠在模拟海拔5000 m高原环境的低压舱中饲养,灌胃给药,对照组给予等量蒸馏水,连续灌胃10 d后,检测小鼠力竭游泳时间、血糖、血乳酸水平和肝糖原含量.结果 与对照组比较,西洋参低、中、高剂量组醇提取液显著延长了小鼠力竭游泳时间、升高了小鼠静息血糖,低、中、高剂量组显著降低了血乳酸曲线下面积,但高剂量组降低了肝糖原含量.结论 西洋参醇提取液具有在高原低氧环境下抗小鼠运动性疲劳的作用,尤以低、中剂量为佳.
Abstract
Objective To explore the anti-fatigue effect of Panax quinquefoiuml in mice under simulated plateau conditions.Methods 100 male KM mice were randomly divided into five groups (n =20):Salidroside,group(0.87 g ·kg-1),Panax quinquefoiuml groups at low(0.29 g ·kg-1),mid(0.86 g ·kg-1) and high(8.6 g· kg-1) dosage.All mice were fed at a simulated altitude of 5000 meters.After ten days of continuous administration,the swimming time,glucose and lactic acid concentration in blood and liver glycogen were determined.Results Compared with control group,the swimming time and blood glucose at rest were significantly increased at each of the tested concentrations (0.29,0.86,8.6 g ·kg-1) ; the area under the blood lactic acid curve was decreased at the concentration of 0.29 and 0.86 g ·kg-1,but there were no significant effects on blood glucose at exhaustion and 20 min after exhaustion.Liver glycogen was decreased in 8.6 g · kg-1 group.Conclusion Panax quinquefoiuml can postpone the onset of fatigue and accelerate recovery from fatigue.
关键词
西洋参/高原/抗疲劳Key words
Panax quinquefoiuml/plateau/anti-fatigue引用本文复制引用
基金项目
国家科技支撑计划(2009BAI85B06)
军队"十一五"攻关资助项目(08G081)
出版年
2013
NETL
NSTL
维普
万方数据