Objective To observe the acute and chronic toxic effect of Tianqihanglifang extract on mice and rats to provide clinical reference.Methods Tianqihanglifang extract was ig administrated to CD-1 (ICR) mice for the acute toxicity test.The adverse drug reaction symptoms and mortality rate were recorded for 14 days.During the long-term toxicity test,SD rats were given Tianqihanglifang extract by intragastric administration for 26 weeks.Examinations concerning hematology,blood biochemistry,pathological morphology and pathological histology were conducted at 13th week,26th week and 4 weeks after drug withdrawal.Results The maximum ig administration dosage of Tianqihanglifang extract was greater than 120 g ·kg-1 in mice.Indexes of hematology,blood biochemistry,pathological morphology and pathological histology of rats were in the normal range and no major organs underwent pathologic changes under a light microscope.Conclusion Tianqihanglifang extract is safe for experimental animals at high dose.
NETL
NSTL
维普
万方数据
