首页|复方三七滴丸质量标准研究

复方三七滴丸质量标准研究

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
目的 建立复方三七滴丸的质量标准。方法 采用薄层色谱法对制剂中的三七进行定性鉴别，高效液相色谱法测定丹参中丹参素的含量，采用ZORBAX SB-C18 色谱柱(4。6 mm×250 mm，5 μm);流动相为甲醇-水-冰醋酸(8∶91∶1);流速:1。0 ml·min-1;检测波长:280 nm。结果 薄层色谱鉴别样品斑点清晰，阴性对照无干扰;在0。5～10。0 μg的范围内，丹参素钠呈良好的线性关系(r=0。9992，n=7)。加样回收率为99。8%，RSD值为0。6%。结论 建立的质量标准方法准确、重复性好、结果可靠，能有效控制复方三七滴丸的质量。
Determination of Compound Sanqi Dripping Pills by HPLC
Objective To establish a quality control method for compound Sanqi dripping pills.Methods Notoginseng in compound Sanqi dripping pills was identified via TLC.The content of salvianic acid A sodium was determined by HPLC with the ZORBAX SB-C18 column(4.6 mm×250 mm,5 μm).The mobile phrase was composed of methanl-water-1%acetic acid(8∶91∶1)at a flow rate of 1.0 ml·min-1 and detected at 280 nm.Results The spots in TLC were clear without any interference.Salvianic acid A showed a good linearity in the range of 0.5 to 10.0 μg(r=0.9992,n=7).The average recovery was 99.8%,with an RSD of 0.6%.Conclusion This method is simple and reliable,which can be used for qual-ity control of compound Sanqi pills.

HPLCcompound Sanqi dripping pillssalvianic acid A

李思治、王剑丽、刘彬果

展开 >

300142 天津,联勤保障部队第983医院

高效液相色谱法 复方三七滴丸 丹参素

2024

10.3969/j.issn.1008-9926.2024.01.001

解放军药学学报
中国人民解放军总后勤部卫生部 药品仪器检验所

解放军药学学报

影响因子：0.529
ISSN：1008-9926
年,卷(期)：2024.37(1)
  • 13