Active Components and Mechanism of Scutellaria Baicalensis Georgi against Acne Based on Network Pharmacology
Objective To analyze the active components and potential molecular mechanism of Scute-llaria baicalensis Georgi against acne based on network pharmacology approaches.Methods The compo-nents and core targets of Scutellaria baicalensis Georgi were screened via the TCMSP database,The target genes related to acne were retrieved from GeneCards,OMIM and TTD databases while the common targets of drugs and related diseases were obtained using Cytoscape 3.8.2 software to construct the target network to screen key active ingredients.Protein interaction analysis was performed through the String platform to construct a PPI network and screen key target genes.GO enrichment analysis and KEGG pathway enrich-ment analysis were performed on common targets using the David database.Results Twenty-eight compounds of Scutellaria baicalensis Georgi and 35 effective targets were screened out.The PPI network found that PTGS2,PTGS1,PRKACA,AR,NOS2 and PIK3CG were the key targets for Scutellaria baicalensis Georgi.KEGG pathway analysis revealed TP53 pathways in cancer,HTLV-I infection,TNF signaling pathway and PI3K-AKT signaling pathway.Conclusion Multiple components,targets,and path-ways are involved in the mechanism of action by which Scutellaria baicalensis Georgi is effective for acne.
NETL
NSTL
万方数据
