首页|临床药师对结肠癌患者化疗联合西妥昔单抗治疗后致带状疱疹的药学监护

临床药师对结肠癌患者化疗联合西妥昔单抗治疗后致带状疱疹的药学监护

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目的 探讨临床药师在结肠癌患者化疗联合西妥昔单抗治疗后致带状疱疹治疗过程中的作用,以期为此类患者的药学监护提供参考.方法 临床药师参与1例结肠癌患者化疗联合西妥昔单抗治疗后伴发带状疱疹的治疗过程.该患者确诊结肠癌采用化疗联合西妥昔单抗靶向治疗2周期后出现带状疱疹.医师予静脉滴注阿昔洛韦500 mg抗病毒治疗、肌肉注射腺苷钴胺1.5 mg营养神经、外用涂抹炉甘石洗剂适量.临床药师查阅相关文献资料,明确带状疱疹诊疗规范,协助临床医师优化抗病毒药物和带状疱疹后神经痛药物选择及临床应用,并对患者进行药学监护.结果 临床医师采纳药师建议;患者经对症治疗后明显好转,继续行抗肿瘤治疗.结论 在结肠癌患者化疗联合西妥昔单抗治疗后伴发带状疱疹治疗过程中,临床药师协助医师完善治疗方案,对患者进行安全合理用药教育和药学监护,对保证治疗有效性、实现药师专业价值具有重要意义.
Pharmaceutical Care for One Patient with Colon Cancer Complicated with Herpes Zoster after Chemotherapy Combined with Cetuximab
Objective To explore the role of a clinical pharmacist in the treatment of herpes zoster caused by chemotherapy combined with cetuximab in one patient with colon cancer in order to provide reference for pharmaceutical care for such patients.Methods One clinical pharmacist participated in the treatment of a patient with colon cancer complicated with herpes zoster after chemotherapy combined with cetuximab.The patient was diagnosed with colon cancer and received chemotherapy combined with targe-ted therapy of cetuximab.Herpes zoster developed after 2 cycles of therapy.The physician prescribed acy-clovir 500 mg intravenous infusion for antiviral therapy,1.5 mg cobamamide intramuscular for nerve nutri-tion,and calamine lotion for external use.The clinical pharmacist referred to related literature,found out more about the diagnosis and treatment of herpes zoster,assisted the physician in optimizing the selection and clinical application of antiviral drugs and herpes zoster neuralgia(PHN)drugs,and provided pharma-ceutical care for the patient.Results The physician adopted the pharmacist's advice.After symptomatic treatment,the patient's symptoms related to herpes zoster improved significantly,and then received anti-tumor treatment.Conclusion During the treatment of herpes zoster in a patient with colon cancer after chemotherapy combined with cetuximab,the clinical pharmacist can assist the physician in improving the treatment plan,informing the patient of safe and rational use of drugs and providing pharmaceutical care,which is of great significance for the therapeutic effect.

colon cancerchemotherapycetuximabherpes zosterpharmaceutical care

徐韬、汪皖青、朱建国、李轶、侯幸赟、伊佳

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215006 江苏苏州,苏州大学附属第一医院

200003 上海,海军军医大学第二附属医院

结肠癌 化疗 西妥昔单抗 带状疱疹 药学监护

2024

解放军药学学报
中国人民解放军总后勤部卫生部 药品仪器检验所

解放军药学学报

影响因子:0.529
ISSN:1008-9926
年,卷(期):2024.37(1)
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