水合氯醛杀菌活性的实验研究
Antibacterial Efficacy of Chloral Hydrate
郭健莲 1王庆芬1
作者信息
- 1. 363000 福建漳州,联勤保障部队第909医院/厦门大学附属东南医院
- 折叠
摘要
目的 考察水合氯醛的杀菌活性.方法 采用悬液定量杀菌方法,考察水合氯醛不同浓度和不同作用时间对金黄色葡萄球菌、铜绿假单胞菌、大肠杆菌和白色念珠菌的杀菌作用.结果 2.5%水合氯醛对金黄色葡萄球菌、铜绿假单胞菌和白色念珠菌杀灭对数值均<3.00;5.0%以上的水合氯醛对铜绿假单胞菌和大肠杆菌的灭菌对数值均>3.00;5.0%和7.5%水合氯醛对金黄色葡萄球菌和白色念珠菌作用2 min杀灭对数值均<3.00,但是提高水合氯醛的浓度或延长作用时间后其杀灭对数值均>3.00.结论 水合氯醛的杀菌效果随着作用时间的延长和浓度的增加而增强;5.0%～10.0%水合氯醛经临床实践具有较高的安全性,可用于临床外科的抗感染治疗.
Abstract
Objective To study the antibacterial efficacy of chloral hydrate.Methods The suspension quantitative killing test was used to determine the ability of chloral hydrate at different concentrations and for differ-ent durations of action to kill Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa and Candida albi-cans.Results The killing logarithm values of 2.5%chloral hydrate for Staphylococcus aureus,Pseudomonas aerug-inosa and Candida albicans were all below 3.00.The killing logarithm values of more than 5.0%chloral hydrate for Pseudomonas aeruginosa and Escherichia coli all exceeded 3.00.The killing logarithm values of 5.0%and 7.5%chloral hydrate for Staphylococcus aureus and Candida albicans after 2 min were all less than 3.00.When the concentration or duration of action was increased,the killing logarithm values were all higher than 3.00.Conclusion The antibacterial efficacy of chloral hydrate can be enhanced with the increase of concentrations and durations of action.Chloral hydrate at the concentrations of 5.0%to 10.0%is safe enough to be used in anti-infec-tion treatment in clinical surgery.
关键词
水合氯醛/杀菌活性Key words
chloral hydrate/antibacterial efficacy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据