Objective To provide data for rational use of statins and prevention of adverse drug reac-tions(ADR).Methods Reports of ADR of statins from 2011 to 2021 were collected.According to the Pareto principle,the types of ADR of statins,basic data of patients,possible influencing factors and outcomes were analyzed.Results A total of 147 ADR of statins were reported and 73.47%of the patients were over 55.The number of combined drugs was 14.29±3.77 for patients over 65,and 10.50±2.31 for those ages 55 to 65.The percentage of liver damage was the highest(70.07%),with other adverse effects manifested in the muscle,skin and nervous system.The median duration of ADR was 4 days.Drugs that were chiefly responsible for these ADR were atorvastatin 40 mg·d-1,atorvastatin 20 mg·d-1,and rosu-vastatin 10 mg·d-1.The duration of ADR was less than 9 d(72.79%)in most of the patients,among who 63 recovered(42.86%)and 71 improved(48.30%).Conclusion When statins are used in patients over 55 years old,clinicians should minimize the drug regimen and avoid prescribing intensive lipid-lower-ing satins.Liver function indicators and other ADR should be monitored four days into the medication.Statins should be withdrawn in case of ADR.
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