Correlations Clinical Characteristics with Inflammatory Indexes in Oxaliplatin-induced Peripheral Neuropathy
Objective To explore the correlations between clinical characteristics and inflammatory factors in patients with oxaliplatin induced peripheral neuropathy(OIPN),and to provide data for studies on the mechanism of neuroinflammatory injury.Methods The basic data of patients with OIPN,clinical manifestations,levels of tumor markers and changes in the results of inflammation-related tests treated in a hospital between September 2021 and August 2023 was retrospectively analyzed.The Pearson method was adopted to analyze the correlations between various inflammation-related indicators while logistic regression was used to analyze the risk factors for OIPN.The area under the ROC curve was used to determine the diagnostic value of these risk factors.Results The incidence of OIPN in this hospital was 82.00%and 53.66%of the patients with OIPN had limb pain(P=0.008).The levels of interleukin-6(IL-6),Creac-tive protein(CRP),Procalcitonin(PCT)in peripheral blood of patients were abnormally elevated and significantly higher than the normal range(P=0.020,P=0.000,P=0.002).The percentage of lympho-cytes and the number of CD3+and CD4+T cells were significantly lower than those of the normal control group(P=0.000,P=0.012,P=0.000).The Pearson method suggested that there was a significant negative correlation between the decreased percentage of lymphocytes and the abnormal increase of CRP(P=0.026).The results of multi-factor logistic regression analysis indicated that IL-6 and CRP were risk factors for OIPN(OR=1.13、1.515,P=0.035、0.008),and the area under the ROC curve suggested that IL-6 and CRP were significant for the diagnosis of OIPN(AUC:0.870、0.886,P<0.05).Conclusion Analysis of the correlations between clinical manifestations and inflammatory index indicators of OIPN could contribute to subsequent studies on the regulatory mechanism OIPN.
peripheral neuropathyoxaliplatininflammatory factorsadverse drug reaction
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