Advances in Pharmacogenetic Research Based on Metabolic Enzymes Related to Safe Pediatric Medication
Pharmacogenetics mainly studies the influence of genetic variables on drug metabolism.Most of pharmacogenetic research has focused on adults,with only a few conducted on pediatrics.The physiological state of children and adults is considerably different,so whether findings of pharmacogenetic studies on adults are applicable to children's treatment remains controversial.This paper reviewed the pedi-atric evidence for pharmacogenetic associations for common drug metabolizing enzymes CYP2C9,CYP2C19,CYP2D6,CYP3A4,CYP3A5,NUDT15,and TPMT,studied the differences between adults and children,and provided reference for safe medication in children.
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