解放军药学学报2024,Vol.37Issue(4) :391-397.DOI:10.3969/j.issn.1008-9926.2024.04.021

纳米药物靶向防治放射性肺损伤的研究进展

Recent Progress in Nanotherapies for Targeted Treatment of Radiation-Induced Lung Injury

钟玲 雷航科 李兰兰 黄定德 张建祥
解放军药学学报2024,Vol.37Issue(4) :391-397.DOI:10.3969/j.issn.1008-9926.2024.04.021

纳米药物靶向防治放射性肺损伤的研究进展

Recent Progress in Nanotherapies for Targeted Treatment of Radiation-Induced Lung Injury

钟玲 1雷航科 2李兰兰 1黄定德 2张建祥1
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作者信息

  • 1. 400038 重庆,陆军军医大学
  • 2. 400038 重庆,陆军军医大学第一附属医院
  • 折叠

摘要

高新技术武器装备的发展,在提高军队战斗力的同时,也在相关作业环境中产生了高强度的电磁辐射.长期的电磁辐射暴露易诱发放射性肺损伤,严重影响军事作业人员的身体健康,然而,日前并没有有效的方案来消除电磁辐射对肺部的损伤.近年来,越来越多的研究表明,纳米药物具有安全性良好、病灶部位靶向性优异、循环时间和体内半衰期长等优势,在放射性肺损伤的防治中展现出了良好的应用前景,本文就纳米药物在防治放射性肺损伤中的应用进行综述.

Abstract

The development of high-tech weapons and equipment has improved the combat effective-ness and competitiveness of the military,but it has also generated high-intensity electromagnetic radiation in related military operational environments.Long-term exposure to electromagnetic radiation can cause radiation-induced lung injury(RILI),posing a severe hazard to the health and quality of life of military personnel.However,there are no effective treatment options to protect the lung health of military person-nel.In recent years,there has been increasing evidence that nanotherapies are promising for the prevention and treatment of RILI as evidenced by their multiple advantages,including good safety,excellent targeting ability and prolonged circulation time in vivo.In this review,the applications of nanotherapies in the treat-ment of RILI are summarized.

关键词

纳米药物/辐射防护/放射性肺损伤/药物递送系统

Key words

nanotherapy/radiation protection/radiation-induced lung injury/drug delivery system

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基金项目

国家自然科学基金(81901866)

重庆市科技创新领军人才(CQYC20210302362)

出版年

2024
解放军药学学报
中国人民解放军总后勤部卫生部 药品仪器检验所

解放军药学学报

CSTPCD
影响因子:0.529
ISSN:1008-9926
参考文献量76
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