Objective To evaluate the applicability of positron radiopharmaceuticals in localizing and analyzing epileptogenic foci of epilepsy caused by focal cortical dysplasia(FCD)in children with 11C-Flumazenil(11C-FMZ)and 18F-fluorodeoxyglucose(18F-FDG)PET/MRI.Methods The clinical data of 34 children with epilepsy caused by FCD was retrospectively analyzed,all of whom had received 11C-FMZ and 18F-FDG brain PET/MRI before treatment.Using SEEG or intraoperative localization as diagnostic criteria,the hypometabolic range and characteristics of 11C-FMZ and 18F-FDG PET were qualitatively ana-lyzed before the efficacy of lateralization and localization was compared.Results Among the 34 children with FCD,44 epileptogenic foci were found Twenty-six of these cases were single and uniform epileptogen-ic foci,5 showed multiple lesions of the cortex(3 located on the same side,and 2 involving the bilateral cortex),and 3 were mixed epileptogenic foci of the cortex and deep brain nuclei.The accuracy of 18F-FDG and 11C-FMZ PET in the diagnosis of fixed lateral epileptogenic foci was 85.29%(29/34)and 82.35%(28/34),respectively,without significant statistical difference.In terms of assessment of the number and loca-tion of lesions,the accuracy of the two was 65.90%(29/44)and 86.36%(38/44),respectively,and the difference was statistically significant(P<0.05).Conclusion The positron radiopharmaceutical-11C-FMZ-can accurately localize and diagnose the epileptogenic focus of FCD-induced epilepsy before surgery.
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