Effect of Positron Radiopharmaceuticals on Localization of Epileptogenic Foci of Epilepsy Caused by Focal Cortical Dysplasia in Children
Objective To evaluate the applicability of positron radiopharmaceuticals in localizing and analyzing epileptogenic foci of epilepsy caused by focal cortical dysplasia(FCD)in children with 11C-Flumazenil(11C-FMZ)and 18F-fluorodeoxyglucose(18F-FDG)PET/MRI.Methods The clinical data of 34 children with epilepsy caused by FCD was retrospectively analyzed,all of whom had received 11C-FMZ and 18F-FDG brain PET/MRI before treatment.Using SEEG or intraoperative localization as diagnostic criteria,the hypometabolic range and characteristics of 11C-FMZ and 18F-FDG PET were qualitatively ana-lyzed before the efficacy of lateralization and localization was compared.Results Among the 34 children with FCD,44 epileptogenic foci were found Twenty-six of these cases were single and uniform epileptogen-ic foci,5 showed multiple lesions of the cortex(3 located on the same side,and 2 involving the bilateral cortex),and 3 were mixed epileptogenic foci of the cortex and deep brain nuclei.The accuracy of 18F-FDG and 11C-FMZ PET in the diagnosis of fixed lateral epileptogenic foci was 85.29%(29/34)and 82.35%(28/34),respectively,without significant statistical difference.In terms of assessment of the number and loca-tion of lesions,the accuracy of the two was 65.90%(29/44)and 86.36%(38/44),respectively,and the difference was statistically significant(P<0.05).Conclusion The positron radiopharmaceutical-11C-FMZ-can accurately localize and diagnose the epileptogenic focus of FCD-induced epilepsy before surgery.
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