Risk Factors for Vancomycin-related Acute Renal Injury
Objective To analyze the risk factors for acute kidney injury in patients using Vancomy-cin.Methods The collected cases were divided into the acute kidney injury group and non-nephrotoxicity group by the standards for kidney injury.Chi-square test was used for a comparison to identify possible risk factors that were evaluated via logistic regression analysis.Results A total of 57 patients with acute kidney injury and 104 patients without were included in this study.The differences in dosage(P=0.007),levels of obesity(BMI≥30,P=0.010 4),age(≥80 years old,P<0.001),trough concentrations(≥30 mg·L-1,P=0.033 8),complications with cardiac insufficiency(P=0.016),incidence of shock(P=0.006)and other underlying diseases of hemodynamic instability and combined use of high-dose diuretics(P=0.033)were statistically significant.Multivariate logistic regression analysis showed that complications with shock(OR=11.832)and age≥80 years(OR=15.77)made the greatest difference.Conclusion The results show that the incidence of Vancomycin-induced acute kidney injury is high,and special attention should be paid to patients at risk.
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