Adverse Reactions Caused by β-Lactam Antibiotics and Evaluation of Drug Safety
Objective To analyze the causes of adverse drug reaction(ADR)of β-lactam antibiotics in our hospital and provide data for safe clinical use.Methods The clinical data of 43 patients who developed ADRs after using β-lactam antibiotics was collected before the incidence,outcomes,types and causes of ADRs,drugs involved,administration methods,systems involved were statistically analyzed across age groups.Results Among the 43 ADR patients,the incidence of ADRs was the highest among those over 65 years old,followed by those age 51-64.The onset time of ADRs ranged from 1 minute to 13 days,and most of the ADRs occurred 60 minutes later.Drugs for intravenous infusion,such as cefoperazone sodium and sulbactam sodium for injection,were most likely to cause ADRs.The ADRs mostly involved damage to the skin and its accessories.After discontinuation of medication or symptomatic treatment,both groups improved or recov-ered.Factors related to the incidence of ADRs included a history of allergies,allergic constitution,smoking or alcohol consumption.Conclusion In clinical practice,some special populations should use β-lactamide antibiot-ics with caution to improve their clinical rational use,efficacy,and safety.
β-lactamide antibioticsadverse drug reactiondrug safety
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