A Pharmaceutical Service Model Based on Influencing Factors of Drug-induced Liver Injury
Objective To analyze the clinical characteristics,influencing factors and rationality of the use of hepatoprotective drugs in patients with drug-induced liver injury(DILI),and to establish a new model of standardized pharmaceutical services.Methods The clinical data of inpatients diagnosed with DILI in our hospital were collected,and the age,gender,suspected drugs,clinical classification,RUCAM score,severity of liver damage,and prognosis were statistically analyzed.A total of 235 DILI patients were divided into the control group(116 cases)and intervention group(119 cases)using the historical control study method.The intervention group received standardized pharmaceutical services besides those enjoyed by the control group.Results The male-to-female ratio of the 235 patients with DILI was 1∶1.4,and the top three drugs that caused DILI were antineoplastic drugs,traditional Chinese medicines or Chinese patent medicines,and anti-infective drugs.The severity of DILL was divided into<severity of grade 3(196 cases)and severity grade≥3(39 cases),and the results of multivariate logistic regression analysis showed that TBIL was an independent influencing factor for the occurrence of severe DILI(P<0.01).The length of hospital stay in the intervention group was significantly shorter than that of the control group(P<0.01).The rate of rational use of hepatoprotective drugs and the patients'medication compliance in the interven-tion group were significantly higher than those of the control group(P<0.01).Conclusion The imple-mentation of individualized medication regimens and standardized pharmacy services for DILI patients can significantly improve patients'medication compliance,increase the rational use of hepatoprotective drugs,shorten the length of hospitalization,and provide strong support for the establishment of a new model of pharmacy services.
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