Objective To explore the mechanism of action of Bidouyan granules based on network pharmacology and molecular docking.Methods The active ingredients and corresponding targets of Bidouyan granules were searched for using the Traditional Chinese Medicine Systems Pharmacology Data-base.Cytoscape 3.8.2 was used to construct a"drug-active ingredient-target"network diagram to screen for key active ingredients.Related targets for sinusitis were retrieved from Drugbank and GeneGards data-bases before being intersected with drug targets to obtain overlapped targets.Protein-protein interaction analysis and visualization were conducted in the String database to screen for key targets for the treatment of sinusitis.Finally,overlapped targets underwent enrichment analysis,and key components and targets were molecularly docked.Results There were 90 active components,452 targets of active components,89 targets of active components and disease intersection.Enrichment analysis found that the common targets might affect the prognosis of patients with sinusitis by regulating immune-related pathways.Molecular docking results showed that the core targets had good binding properties with key compounds.Conclusion Bidouyan granules are found to play a role in treating sinusitis through the combination of active ingredients and targets,which is expected to provide data for subsequent treatment,research and clinical applications.
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