人参皂苷神经保护作用研究进展
Research Progress in Neuroprotective Effect of Ginsenosides
王维刚 1林瑶 1巨佳 1赵锐帆 1冯斌 1薛晓娟 1成黎霏1
作者信息
- 1. 710032 陕西西安,空军军医大学第三附属医院,口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔生物工程工程技术研究中心
- 折叠
摘要
人参皂苷是人参中的主要活性成分,具有抗神经炎症、抗氧化应激、抗凋亡和增强记忆力等药理活性.神经损伤疾病包括阿尔茨海默病、帕金森病、脑卒中等,现代药理研究表明,人参皂苷尤其是人参皂苷单体Rg1、Rb1可通过抗氧化、抑制炎症反应、保护神经元等防治阿尔茨海默病、帕金森病、脑卒中等神经退行性疾病,在神经保护方面展现出了良好开发应用前景.本文对近年来人参皂苷神经保护作用的研究进展予以综述,旨在为人参皂苷的开发研究提供参考.
Abstract
Ginsenosides are the main active ingredients in ginseng,which have pharmacological activities such as anti-neuroinflammation,anti-oxidative stress,anti-apoptosis and enhancing memory.Neurological injury diseases include Alzheimer's disease and Parkinson's disease,stroke.Modern pharmacological studies have shown that ginsen-osides,especially ginsenoside monomers Rg1 and Rb1,can prevent and treat neurodegenerative diseases such as Alzhe-imer's disease,Parkinson's disease and stroke by combating oxidation,inhibiting inflammatory response,and protec-ting neurons,showing a good prospect for development and application in neuroprotection.In this paper,the research progress in the neuroprotective effect of ginsenosides in recent years is reviewed,which is expected to provide a refer-ence for the development and research of ginsenosides.
关键词
人参皂苷/神经保护/阿尔茨海默病/帕金森病/抑郁Key words
ginsenoside/neuroprotection/Alzheimer's disease/Parkinson's disease/depression引用本文复制引用
出版年
2024
NETL
NSTL
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