CypA/CD147在SARS-CoV-2感染性心血管疾病诊疗中的作用研究进展

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中文摘要：新型冠状病毒感染(COVID-19)疫情当前已得到有效控制，然而其相关并发症仍不容忽视，尤其是心血管循环系统更是新型冠状病毒(SARS-CoV-2)活跃的场所。血管紧张素转换酶2(ACE2)是一种高表达于心脏、肾脏和睾丸的Ⅰ型跨膜糖蛋白，新型冠状病毒刺突蛋白通过结合细胞表面受体ACE2入侵宿主细胞，但以此为靶点研发的疫苗、药物在临床应用中仍存在诸多不足。亲环素A(CypA)作为分子伴侣可促进蛋白质折叠及T细胞活化，CD147是研究最为广泛的CypA受体之一，CypA/CD147相互作用在新型冠状病毒进入宿主细胞时发挥重要作用，但新型冠状病毒通过CypA/CD147信号通路入侵心血管系统的研究鲜有报道。基于此，本文在总结前期研究证据并结合课题组研究的基础上，通过对CypA/CD147结构功能、CypA/CD147在心血管疾病中的作用及新型冠状病毒靶向CypA/CD147信号通路引发的心血管疾病进行综述，以期为COVID-19感染并发心血管系统疾病的诊疗提供参考。

外文标题：Progress on effect of CypA/CD147 in diagnosis and treatment of cardiovascular system disease infected by SARS-CoV-2

外文摘要：Corona virus disease 2019(COVID-19)epidemic has been effectively controlled,but its related complications still cannot be ignored,especially the cardiovascular circulatory system is the active site of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Angiotensin-converting enzyme 2(ACE2)is a type Ⅰ transmembrane glycoprotein that is highly expressed in heart,kidney and testis.Spike protein of SARS-CoV-2 invades host cells by binding to the cell surface receptor ACE2.However,there are still many deficiencies in the clinical application of vaccines and drugs developed based on this target.As a molecular chaperone,cyclophilin A(CypA)promotes protein folding and T cell activation.CD147 is one of the most widely studied CypA receptors,and the interaction of CypA/CD147 plays an important role in the entry of SARS-CoV-2 into host cells.However,there are few reports on the invasion of SARS-CoV-2 into the cardiovascular system through the CypA/CD147 signaling pathway.Based on this,this article summarizes the previous research evidence and the research basis of the research group,and reviews the structure and function of CypA/CD147,the role of CypA/CD147 in cardiovascular disease,and the cardiovascular disease caused by SARS-CoV-2 targeting CypA/CD147 signal pathway,in order to provide reference for the diagnosis and treatment of the COVID-19 complicated with cardiovascular system diseases.

外文关键词：

cyclophilin Aextracellular matrix metalloproteinase inducersevere acute respiratory syndrome coronavirus 2cardiovascular systemcardiovascular diseases

作者：

马明仁、王菲、蔡晓庆、刘燕、马凌

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作者单位：

解放军联勤保障部队第940医院心血管内科,甘肃兰州 730050

关键词：

亲环素A 细胞外金属蛋白酶诱导剂新型冠状病毒心血管系统心血管疾病

基金：

甘肃省自然科学基金甘肃省自然科学基金解放军联勤保障部队第940医院院内项目解放军联勤保障部队第940医院院内项目解放军联勤保障部队第940医院院内项目

项目编号：

21JR1RA181GSWSKY2020-012021yxky0802021yxky0722021yxky031

出版年：

2024

DOI：

10.11855/j.issn.0577-7402.0493.2023.0915

解放军医学杂志

人民军医出版社

解放军医学杂志

CSTPCD北大核心

影响因子：1.644

ISSN：0577-7402

年,卷(期)：2024.49(1)

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