解放军医学杂志2024,Vol.49Issue(3) :329-334.DOI:10.11855/j.issn.0577-7402.2392.2023.1007

超敏肌钙蛋白在慢性肾脏病合并急性心肌梗死中的作用研究进展

Research progress of high-sensitivity troponin in chronic kidney disease with acute myocardial infarction

马玉娇 谢萍 汪蒙 王茸
解放军医学杂志2024,Vol.49Issue(3) :329-334.DOI:10.11855/j.issn.0577-7402.2392.2023.1007

超敏肌钙蛋白在慢性肾脏病合并急性心肌梗死中的作用研究进展

Research progress of high-sensitivity troponin in chronic kidney disease with acute myocardial infarction

马玉娇 1谢萍 2汪蒙 3王茸1
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作者信息

  • 1. 兰州大学第一临床医学院,甘肃兰州 730000
  • 2. 兰州大学第一临床医学院,甘肃兰州 730000;甘肃省人民医院心内科,甘肃兰州 730000
  • 3. 甘肃省人民医院干部心内科,甘肃兰州 730000
  • 折叠

摘要

肌钙蛋白检测技术的进步及临床应用,使急性心肌梗死(AMI)的诊断率不断提高,有效缩短了坏死心肌再灌注时间.研究发现,慢性肾脏病(CKD)患者超敏肌钙蛋白(hs-cTn)水平存在不同程度的升高,因此,当CKD患者发生AMI时,hs-cTn的应用受到一定限制,加之CKD患者缺乏非特异性的胸痛症状及心电图表现,如何快速准确地诊断此类患者变得尤为困难.基于此,本文从hs-cTn在AMI中的应用、CKD合并AMI患者的临床特征、如何改善CKD合并AMI患者的诊断准确率,以及hs-cTn在此类患者风险分层及预后评估中的价值等方面进行综述,旨在为患者进行早期干预或血运重建提供参考.

Abstract

The progress and clinical application of troponin detection technology have continuously improved the diagnosis rate of acute myocardial infarction(AMI),which effectively shortens the time of necrotic myocardial reperfusion.Earlier studies have found that high-sensitivity troponin(hs-cTn)is elevated to varying degrees in patients with chronic kidney disease(CKD).Therefore,when patients with CKD have AMI,the application of hs-cTn is limited to a certain extent,and with the lack of chest pain symptoms and the non-specificity of electrocardiogram performance in patients with CKD,it is particularly difficult to make a quick and accurate diagnosis of such patients.Based on this,this article will summarize the application of hs-cTn in AMI,the clinical characteristics of patients with CKD combined with AMI,how to improve the diagnostic accuracy of patients with CKD combined with AMI,and the value of hs-cTn in risk stratification and prognosis assessment of such patients to provide clinical medical staff with reference for early intervention or revascularization of patients.

关键词

超敏肌钙蛋白/急性心肌梗死/慢性肾脏疾病

Key words

high-sensitivity troponin/acute myocardial infarction/chronic kidney disease

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基金项目

国家自然科学基金(81860047)

出版年

2024
解放军医学杂志
人民军医出版社

解放军医学杂志

CSTPCDCSCD北大核心
影响因子:1.644
ISSN:0577-7402
参考文献量42
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