摘要
癫痫是一种突发性脑部神经元高度同步化反复异常过度放电引起短暂性脑功能失调的慢性疾病.中枢神经系统内特定区域的炎症反应是癫痫的共同特征.近年来越来越多证据显示内质网应激参与癫痫的病理过程,可激活未折叠蛋白反应,进而通过调控核因子κB(NF-κB)途径引发促炎信号的释放,诱导胶质细胞激活,而过度激活的胶质细胞通过介导神经炎症影响癫痫发生、发作.本文综述了内质网应激及胶质细胞激活介导的神经炎症在癫痫病理过程中作用的研究进展,以期为加深对癫痫的认识提供参考.
Abstract
Epilepsy is a chronic disease characterized by recurrent,sudden,and excessive synchronous discharge of neurons in the brain,leading to transient brain dysfunction,and inflammatory responses in specific regions within the central nervous system are common features of epilepsy.In recent years,there has been increasing evidence that endoplasmic reticulum stress is involved in the pathology of epilepsy,which activates the unfolded protein response,then regulate and control nuclear factor kappa-B(NF-κB),efficiently induces glial cell activation through the release of pro-inflammatory signals,in turn affects epileptogenesis and seizures by triggering neuroinflammation.This review focuses on the close link between endoplasmic reticulum stress and glial cell activation-mediated neuroinflammation in epilepsy pathology,aiming to provide insights for a deeper understanding of epilepsy.
基金项目
山东省中医药科技发展计划项目(2019-0108)
山东省中医药科技项目(2020M004)
齐鲁内科血浊学术流派传承工作室项目(鲁卫函[2021]45号)
国家科技期刊平台
NSTL
万方数据