Research progress on the role of M1/M2 macrophages in hepatic fibrosis
Hepatic fibrosis refers to repeated or persistent inflammation and necrosis of liver parenchymal cells and excessive deposition of liver fibrous connective tissue caused by various etiologies,which is a necessary stage for chronic liver disease to develop into cirrhosis.Etiological treatment as antiviral therapy can reduce the inflammation of the liver tissues to a certain degree,but cannot completely stop the process of liver fibrosis.In recent years,researchers have found that intrahepatic macrophages play an important role in the occurrence and progression of hepatic fibrosis,among which M1/M2 macrophages have become the key to exploring macrophages to regulate hepatic fibrosis.This article will focus on the role and mechanism of intrahepatic M1/M2 macrophages in hepatic fibrosis.
国家科技期刊平台
NSTL
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