M1/M2型巨噬细胞在肝纤维化中的作用研究进展
Research progress on the role of M1/M2 macrophages in hepatic fibrosis
杨钰萌 1王新 2麻婧2
作者信息
- 1. 西安医学院研究生工作部,陕西西安 710021;空军军医大学第二附属医院(唐都医院)消化内科,陕西西安 710032
- 2. 空军军医大学第二附属医院(唐都医院)消化内科,陕西西安 710032
- 折叠
摘要
肝纤维化是指各种病因导致反复或持续的肝脏实质细胞炎症、坏死,以及肝脏纤维结缔组织过度沉积的结果,是慢性肝病发展为肝硬化的必经阶段.抗病毒等病因治疗可一定程度减轻肝组织炎症,但无法完全终止肝纤维化进程.近年来研究发现,肝内巨噬细胞在肝纤维化的发生发展中发挥平衡炎症、调节免疫功能等重要作用,巨噬细胞的回输可延缓肝纤维化,其中M1/M2型巨噬细胞已成为探索巨噬细胞调节肝纤维化的关键.本文重点阐述肝内M1/M2型巨噬细胞在肝纤维化中的作用及其机制.
Abstract
Hepatic fibrosis refers to repeated or persistent inflammation and necrosis of liver parenchymal cells and excessive deposition of liver fibrous connective tissue caused by various etiologies,which is a necessary stage for chronic liver disease to develop into cirrhosis.Etiological treatment as antiviral therapy can reduce the inflammation of the liver tissues to a certain degree,but cannot completely stop the process of liver fibrosis.In recent years,researchers have found that intrahepatic macrophages play an important role in the occurrence and progression of hepatic fibrosis,among which M1/M2 macrophages have become the key to exploring macrophages to regulate hepatic fibrosis.This article will focus on the role and mechanism of intrahepatic M1/M2 macrophages in hepatic fibrosis.
关键词
肝纤维化/巨噬细胞/细胞外基质Key words
hepatic/liver fibrosis/macrophages/extracellular matrix引用本文复制引用
基金项目
空军军医大学临床研究重点项目(2021LC2114)
出版年
2024
国家科技期刊平台
NSTL
万方数据