Research progress on the relationship between abnormal uric acid metabolism and type 2 diabetes mellitus
Uric acid,the end product of purine metabolism in human body,can lead to uric acid metabolism abnormality when its production and excretion are out of balance.This abnormality has emerged as one of the important risk factors for metabolic diseases,including diabetes,obesity,hypertension and metabolic syndrome.Recent studies have found that abnormal uric acid metabolism increases the risk of occurrence and development of type 2 diabetes mellitus(T2DM)and its complications,suggesting that uric acid metabolism could be a novel approach for intervening in T2DM.This review summarizes the research progress on how uric acid metabolism abnormality influences the occurrence,development and pathogenesis of T2DM,the beneficial effects of uric acid-lowering therapy,and the selection of hypoglycemic drugs on T2DM,which provide evidence for the early prevention and treatment of T2DM and its complications.
万方数据
