间充质干细胞调控免疫反应治疗创伤性脑损伤的作用机制研究进展
Research progress on the role of mesenchymal stem cells in regulating immune response for treatment of traumatic brain injury
高洋 1秦合伟 2刘丹丹1
作者信息
- 1. 河南中医药大学康复医学院,河南 郑州 450046
- 2. 河南中医药大学康复医学院,河南 郑州 450046;河南中医药大学第二附属医院康复医学科,河南 郑州 450000
- 折叠
摘要
创伤性脑损伤(TBI)是世界范围内死亡或残疾的重要原因,严重危害公众的健康和生活质量.TBI按病理机制可分为原发性脑损伤和继发性脑损伤,其中脑损伤后免疫细胞过度浸润诱发的神经炎症是继发性脑损伤级联反应形成的重要机制之一.目前,TBI缺乏针对性的治疗药物,主要依赖对症治疗.间充质干细胞的免疫调节特性作为治疗脑损伤的潜在机制应用前景较好,可介导免疫反应减轻神经炎症,修复神经损伤.本文综述了TBI发生后的免疫应答及间充质干细胞的免疫调节作用的相关研究进展,以期为后续研究和临床应用提供参考.
Abstract
Traumatic Brain Injury(TBI)is a significant global cause of mortality and disability,severely compromising public health and quality of life.TBI can be divided into primary and secondary brain injuries according to pathological mechanism,with excessive infiltration of immune cells post-injury triggering neuroinflammation being one of the crucial mechanisms in the cascade of secondary brain injury.Currently,There is a lack of targeted therapeutic agents for TBI,and treatment mainly relies on symptomatic care.Mesenchymal stem cells(MSCs)have shown promising potential in the treatment of brain injury through their immune-modulatory properties,which can mediate immune responses to reduce neuroinflammation and repair nerve damage.The review summarizes the recent research progress on immune responses following TBI and the immune regulatory effects of MSCs,aiming to provide references for subsequent research and clinical applications.
关键词
创伤性脑损伤/间充质干细胞/免疫调节/血脑屏障/作用机制Key words
traumatic brain injury/mesenchymal stem cells/immunomodulation/blood-brain barrier/action mechanism引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据