A Meta-analysis of the Predictive Value of Calcitoninogen for Anastomotic Fistula After Colorectal Surgery
Objective To investigate the value of calcitoninogen(PCT)to predict anastomotic leakage(AL)after colorectal surgery using meta-analysis.Methods We searched literature about predicting the risk of anastomotic leakage after colorectal surgery with calcitoninogen in eight major databases,including PubMed,CNKI,and CBM,for the keywords ″anastomotic leakage″,″anastomotic fistula″,and ″calcitoninogen″.The studies that met the inclusion and exclusion criteria were evaluated by QUADAS-2 risk of bias and visualized using Review Manager 5.3 software to determine the final literature for inclusion in the Meta-analysis,and Stata 14.0 and Meta DiSc 1.4 software were used to analyze the diagnostic value of calcitoninogen on anastomotic leakage after colorectal surgery.Results A total of 455 papers were searched with the corresponding keywords,and 10 papers were finally categorized.Meta-analysis suggested that the combined sensitivity of PCT on postoperative day 5 for predicting AL after colorectal surgery in the included literature was 0.85(95%CI(0.76,0.91)),and the combined specificity was 0.85(95%CI(0.83,0.87)).The combined AUC=0.914 9 and Q-index=0.847 5;the combined diagnostic ratio DOR was 32.89(95%CI(17.44,62.03)).Conclusion PCT in the laboratory on the fifth postoperative day to predict AL after colorectal surgery has important clinical value.
万方数据
维普
