Early Prediction Value of Four Biomarkers Combined Detection for Refractory Mycoplasma Pneumoniae Pneumonia in Children
Objective To investigate the value of multiple biomarkers in predicting refractory Mycoplasma pneumoniae pneumonia(RMPP)in children.Methods A total of 186 children with MPP admitted from March 2021 to August 2022 were selected and divided into RMPP group(65 cases)and GMPP group(121 cases)according to the severity of the disease.The erythrocyte sedimentation rate(ESR),ferritin(SF),lactate dehydrogenase(LDH),D-dimer(D-D)expression levels and related indicators were compared between the two groups at admission.Multivariate logistic regression analysis was performed,and ROC curve was used to analyze the predictive value.Results Compared with the GMPP group,the RMPP group had a higher incidence of high fever,pleural effusion,lung consolidation,and atelectasis(P<0.05),and a longer hospital stay(P<0.05).The expression levels of NEUT%,IL-6,IL-8,CRP,ESR,SF,LDH and D-D in RMPP group were higher than those in GMPP group(P<0.05).Multivariate logistic regression analysis showed that pleural effusion,lung consolidation,atelectasis,ESR,SF,LDH and D-D were independent predictors of RMPP(P<0.05).ROC curve showed that the AUC of ESR,SF,LDH and D-D combined to predict RMPP was 0.946,which was larger than that of the single detection of above markers(Z=6.097,5.804,4.835,4.191,P<0.05).Conclusion The levels of ESR,SF,LDH and D-D in children with RMPP are significantly increased,and the combined detection of these four biomarkers could further improve the predictive value of RMPP.
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