摘要
目的:分析干扰素诱导跨膜蛋白 3(IFITM3)、结构域蛋白 7(BTBD7)、多瘤病毒增强子激活剂 3(PEA3)在非小细胞肺癌(NSCLC)中的表达及相关性研究.方法:选取 2021 年 2 月～2022 年 2 月江门市人民医院进行肺癌手术治疗的 80例患者为研究对象,在进行手术过程中,切取其肺癌患者癌组织,为本研究组织标本,同时切取相应的癌旁组织,进行数据的比较.使用免疫组化法检测IFITM3、BTBD7、PEA3 表达.观察IFITM3、BTBD7、PEA3 在非小细胞肺癌中的表达及相关性.结果:与癌旁组织比较,癌组织IFITM3、BTBD7、PEA3 阳性表达率升高,差异有统计学意义(P<0.05).NSCLC组织IFITM3、BT-BD7、PEA3 表达与患者年龄、性别、肿瘤直径、吸烟史、组织学分型比较差异均无统计学意义(P>0.05).NSCLC组织中于IF-ITM3、BTBD7、PEA3 表达于TNM分期、分化程度、胸膜转移、淋巴结转移,差异均有统计学意义(P<0.05).NSCLC组织IF-ITM3、BTBD7 之间表达呈正相关(r=0.518,P=0.001);NSCLC组织BTBD7、PEA3 表达呈正相关(r=0.604,P=0.001);NSCLC组织IFITM3、PEA3 表达呈正相关(r=519,P=0.001).结论:NSCLC IFITM3、BTBD7、PEA3 表达呈上调状态,三者之间具有密切相关性,与其表达的高低变化与TNM分期、分化程度、胸膜转移、淋巴结转移等临床病理症状之间具有相关性,由此表明,IFITM3、BTBD7、PEA3 可能参与NSCLC的发展过程.
Abstract
Objective The expression and correlation of interferon-induced interferon-induced transmembrane protein 3(IFITM3),Domain protein 7(BTBD7)and Polyomavirus enhancer activator 3(PEA3)in non-small cell lung cancer were analyzed.Method 80 patients who underwent lung cancer surgery in our hospital from February 2021 to February 2022 were selected.During the operation,the cancer tissues of the patients with lung cancer were excised as the tissue specimens for this study,and the corresponding adjacent tissues were excised at the same time.Compare the data.The expressions of IFITM3,BTBD7 and PEA3 were detected by immunohisto-chemistry.Results Compared with adjacent tissues,the positive expression rate of IFITM3,BTBD7 and PEA3 were increased and were statistically different(P<0.05).IFITM3,BTBD7 and PEA3 expression were not varied from patient age,sex,tumor diameter,smoking history and histological type(P>0.05).IFITM3,BTBD7,and PEA3 were expressed in TNM stage,differentiation degree,pleural metas-tasis,and lymph node metastasis(P<0.05).IFITM3,BTBD7 and expression in non-small cell lung cancer(r=0.518,P=0.001);A positive correlation was observed between BTBD7 and PEA3 expression in non-small cell lung cancer tissues(r=0.604,P=0.001);A positive correlation was observed between IFITM3 and PEA3 expression in non-small cell lung cancer tissues(r=519,P=0.001).Con-clusion Non-small cell lung cancer IFITM3,BTBD7,PEA3 expression,has a close correlation between the three,its expression changes and TNM stage,differentiation,pleural metastasis,lymph node metastasis and other clinicopathological symptoms,correlation,thus shows that IFITM3,BTBD7,PEA3 may participate in the development of non-small cell lung cancer.
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