Prognostic evaluation of routine treatment for acute exacerbation of chronic obstructive pulmonary disease with different spatial distributions of emphysema
Objective To observe of the prognosis of chronic obstructive pulmonary disease with different spatial distributions after routine treatment in acute exacerbation of emphysema.Method 69 patients with acute exacerbation of chronic obstructive pulmonary disease were selected,according to HRCT results,33 cases of upper lobe-based emphysema(ULE)type and 36 cases of lower lobe-based emphysema(LLE)type.General information were established.All patients were given routine treatment,and the CAT scale measurement score,mMRC score,blood gas analysis,lung function,hospitalization days after treatment were recorded,and the next hospitalization interval and the number of acute exacerbations in the next year were followed up.Results CAT,mMRC score,FEV1%pred,FEV1/FVC,PaO2 and PaCO2 levels after treatment were significantly improvement in each group(P<0.05);but compared the upper lobe-based emphysema with the lower lobe-based emphysema,there was no significant difference in the improvement of indicators(P>0.05).The results suggest that the number of hospital stays in patients with lower lobe-based emphysema was signifi-cantly shorter than that in patients with upper lobe-based emphysema(P<0.05),and that the interval between the lower lobe-based emphysema was slightly longer than that in the upper lobe-based emphysema,but with no statistically significant difference(P>0.05);Through long-term follow-up of patients,the number of acute exacerbations in the lower lobe-based emphysema was significant-ly higher than that in the upper lobe-based emphysema(P<0.05).Conclusion In the acute exacerbation period,there was no signifi-cant difference in the response to conventional treatment between the patients with upper lobe-based emphysema and those with lower lobe-based emphysema,and the hospital stay may be shorter,but the AE in one year may also be more frequent.
Chronic obstructive pulmonary disease(COPD)EmphysemaDifferent spatial distribution ofAcute exacerbation periodConventional therapy
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