Mechanism of yinhua gancao Decoction in treatment of radiation pneumonitis based of network pharmacol-ogy
Objective To explore the effective components and target mechanism of Yinhua Gancao Decoction in the treatment of radiation pneumonitis.Method The effective components and related target proteins of Yinhua Gancao decoction were screened by TC-MSP database,and the target proteins were genetically standardized in Uniport database.Combined with the disease targets of radiation pneumonia in Genecard database,the screened active components of traditional Chinese medicine and the mapping targets were impor-ted into Cytoscape software to construct the active components-target network map.The Enrich database was used to analyze the biologi-cal process of Go and the enrichment of KEGG signal pathway.Results 115 active components of Yinhua Glycyrrhiza decoction were obtained,and 59 targets for the treatment of radiation pneumonia were obtained,which were enriched into 13 biological processes and 61 signal pathways.Thirteen compounds such as kaempferol,luteolin,β-carotene and quercetin may be important active components of Yinhua Glycyrrhiza decoction in the treatment of radiation pneumonia,and five core targets such as PTGS2,NOS2,AKT1,PRARG and MAPK14 were possible targets.These targets were related to 13 biological processes such as MAP kinase activity,protein serine/threonine/tyrosine kinase activity,mitogen-activated protein kinase binding and oxidoreductase activity,and were regulated by 61 sig-nal pathways,such as VEGF signal pathway,small cell lung cancer,C-type lectin receptor signal pathway,TNF signal pathway and so on.Conclusion Yinhua Gancao decoction has a certain therapeutic effect on radiation pneumonia,and its mechanism may be related to the regulation of PTGS2,NOS2,AKT1,PRARG,MAPK14 and other targets,regulation of VEGF signal pathway,small cell lung cancer,C-type lectin receptor signal pathway,TNF signal pathway and other pathways.
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