Effect of intrauterine infusion of HCG combined with dydrogestone on peripheral blood lymphocyte level and pregnancy outcome in patients with recurrent spontaneous abortion
Objective To investigate the effect of intrauterine infusion of HCG combined with dydrogestone on the changes of pe-ripheral blood lymphocyte level and pregnancy outcome in patients with RSA.Method 43 RSA patients who were treated in our hospi-tal were selected as the research objects from January 2019 to October 2020,and they were divided into the research group(n=19)and the control group(n=24).the control group was treated with diprogesterone group,the research group was treated with intrauterine infusion of HCG combined with diprogesterone group.The clinical pregnancy outcomes of peripheral blood lymphocytes,estradiol and progesterone during implantation and three cycles before and after treatment were analyzed.Results There was no significant difference between the two groups in age,times of adverse pregnancy and endometrial thickness on ovulation day(P>0.05);Before treatment,there was no significant difference in E2 and P content between the two groups during implantation(P>0.05).After treatment,the se-rum E2 and P content of the research group and the control group were higher than those before treatment,and the E2 and P content of the research group after treatment were higher than those of the control group,with significant differences(P<0.05);Before and after treatment,there was no significant difference in peripheral blood B lymphocytes,NK cells,CD3+T cells,CD3+CD8+T cells and CD4+/CD8+T cells between the two groups during implantation(P>0.05),but the percentage of CD3+CD4+T cells in peripheral blood of the research group was higher than that before treatment,and the difference was statistically significant compared with that of the control group(P<0.05);The clinical pregnancy rate of the research group was higher than that of the control group,and the spontane-ous abortion rate in the first trimester was lower than that of the control group,there was significant difference between the two groups(P<0.05).Conclusion Intrauterine HCG infusion combined with dydrogestone in the treatment of RSA can improve the clinical preg-nancy rate of RSA patients and reduce the risk of abortion by increasing the estrogen and progesterone levels during the implantation phase and increasing the percentage of CD3+CD4+T cells in peripheral blood lymphocytes.
NETL
NSTL
万方数据
