The effect of butorphanol to prevent the choking response induced by fentanyl
Objective To investigate the clinical value of intravenous butorphanol to inhibit the choking response to fentanyl.Meth-od 80 patients undergoing elective general anesthesia in our hospital were selected as the study subjects from May 2022 to March 2023,with ASA class Ⅰ～Ⅱ,aged 18～70 years,weight 40～90 kg,and were divided equally into two groups using the random num-ber method,each with 40 cases.Group C(control group):0.9%NS 5 ml was given intravenously before induction of anesthesia;Group B(experimental group):bupropion 20 μg/kg(0.9%NS diluted to 5 ml)was given intravenously before induction of anesthe-sia.5 μg/kg of fentanyl was given intravenously 3 min later(injection time was 3 s).The incidence of choking induced within 2 min after fentanyl administration,the severity of choking(1～2 times for mild,3～4 times for moderate,5 times and above for severe),and related adverse effects were recorded;the changes of MAP and HR were observed before(T0),3 min after(T1)and 2 min after(T2)fentanyl injection for 0.9%NS and bupropion.Results Compared with group C,the incidence of choking was significantly lower in group B(P<0.05);the severity of choking was significantly lower in group B than in group C(P<0.05).There was no statisti-cally significant intra-group difference in MAP and HR between the two groups at different time points(P>0.05).Conclusion 20 μg/kg butorphanol can effectively prevent fentanyl-induced choking response during induction of general anesthesia,especially for moderate and severe choking,and there were no drug-related adverse effects.
NETL
NSTL
万方数据
