Objective To investigate the treatment strategies and long-termoutcomes of radiofrequency ablation(RFA)on small hepatocellular carcinoma(SHCC)which conventional two-dimensional gray-scale ultrasound can't show under the background of liver cirrhosis.Method 262 patients(357 nodules)with SHCC who received RFA were screened,these patients were divided into conven-tional ultrasound can't show group(experimental group)and conventional ultrasound can show group(control group).Conventional ul-trasound can't show group was conventional ultrasound can't detect the location and boundary of SHCC which detected by MRI or CT,RFA guided by contrast-enhanced ultrasound or image fusion technology.Complete ablation rates,intrahepatic recurrence rates,dis-ease-free survival(DFS)rates and complication rates were compared between the two groups and analyze prognostic factors of the ex-perimental group.Results There was a significant difference in Intrahepatic distal recurrence(IDR)rates and total recurrence rates be-tween the experimental group and control group(P<0.05).However,the Local tumor progression(LTP)rates in the experimental group was not significantly different from the control group(P=0.440).The 1-,2-,3-,4-,and 5-year IDR-free survival rates and DFS rates were significantly higher in the experimental group compared with the control group(P=0.021),the cumulative tumor free survival rate was relatively high(P=0.020).There was no statistically significant difference in LTP free survival rate(P=0.328).Complete ablation rates and complication rates between two groups has no statistically significant difference(P>0.05).Multivariate a-nalysis identified ablative margin was associated with IDR in experimental group.Conclusion For SHCC under the background of liver cirrhosis,conventional ultrasound can't show SHCC has a lower IDR and higher DFS rates compared with the conventional ultrasound can show SHCC,so we should early detect and treatment these conventional ultrasound can't show SHCC.
维普
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