Correlation between the level of blood lipids and clinical manifestations of the pre-protein converting en-zyme subtilisin 9 in patients with acute ischemic stroke
Objective To explore the correlation between the level of blood lipids and the severity of acute ischemic stroke(AIS)and the level of protein converting enzyme subtilisin 9(PCSK9).Method A total of 200 patients with acute ischemic stroke diagnosed and treated by Tianjin Beichen Hospital were selected as the AIS group,and 200 healthy people were selected as the control group.The clinical data of the two groups of patients were collected,and the levels of lipids and PCSK9 were measured.Patients with AIS were di-vided into mild-moderate group(NIHSS score<15)and severe group(NIHSS score≥15)according the National Institutes of Health Stroke Scale(NIHSS).Pearson correlation analysis was used to explore the correlation between PCSK9 and the level of lipids and the severity in AIS patients.Results The levels of TG,TC,LDL-C and PCSK9 in AIS group were higher than those in the control group(P<0.05),while the levels of HDL-C were lower than those in the control group(P<0.05).The level of PCSK9 in AIS group was correlated with TG,TC,LDL-C and HDL-C(P<0.05).The expression level of PCSK9 in the severe group was significantly higher than that in mild-moderate group(P<0.05).Conclusion Stroke patients are often accompanied by abnormal lipids and elevated PC-SK9 protein level,and there is a certain correlation between PCSK9 protein level and the level of blood lipids and disease severity in AIS patients.
万方数据
维普
