Clinical efficacy of hydromorphone combined with intercostal nerve block in postoperative analgesia after thoracoscopic surgery
Objective To investigate the analgesic effect and safety of hydromorphone combined with intercostal nerve block in post-operative analgesia in patients undergoing thoracoscopic surgery.Method 120 patients underwent thoracoscopic surgery under elective general anesthesia were selected as research object.They were divided into hydromorphone combined with intercostal nerve block group(group H)and sufentanil combined with intercostal nerve block group(group S)with 60 cases in each group.Group H:After surger-y,the intercostoal nerve was blocked under ultrasound guidance.Half an hour before the surgery,2mg hydromorphone and PCIA(hydromorphone 0.2 mg/kg+ondansetron 16mg+ketorolac tropanol injection 120mg+normal saline diluted to 150 mL)were given.The loading dose of PCIA pump is 2ml,the supplementary dose is 2ml,the infusion speed is 2ml/h,and the locking time is 15min.Group S:After surgery,intercostal nerve block was administered under ultrasound guidance,and 10μg Sufentanil was given half an hour before the end of surgery,PCIA(2μg/kg sufentanil+ondansetron 16mg+ketorolac tropanol injection 120mg+normal saline dilu-ted to 100 mL).The loading dose of PCIA pump was 2ml,the supplementary dose was 0.5ml,the infusion speed was 2ml/h,and the locking time was 15min.Ketorolac ambutol injection 30mg was administered intravenously for remedial analgesia,and the VAS score was maintained below 3.The VAS score,Ramsay score,agitation score,the number of intravenous controlled analgesia compressions and the number of ketorolac troamine administration were compared between the two groups.The incidence of postoperative adverse re-actions,including nausea,vomiting and dizziness,and pulmonary complications from postoperative to discharge,were observed in the two groups.Results Compared with group S,the VAS scores of group H at 2h,12h,24h and 48h after operation were lower than those of group S,with statistical significance(P<0.05).There was statistical significance in the incidence of dizziness between the two groups(P<0.05).There was no significant difference in Ramsay score,agitation score,nausea and vomiting,pulmonary complica-tions,analgesic pump compression times,and ketorolac tropanol administration times between group H and group S(P>0.05).Con-clusion Hydromorphone combined with intercostal nerve block is effective in postoperative analgesia in patients undergoing thoraco-scopic surgery and is worthy of clinical application.
HydromorphoneIntercostal nerve blockThoracoscopic surgery
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维普
